Muscimol

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Muscimol

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Cat No: 13667

Biochemicals - Ion Channel Modulation

The amino acid γ-aminobutyric acid (GABA) is an inhibitory neurotransmitter that acts through two families of heteromeric ligand-gated ion channels, GABAA and GABAC and a G protein-coupled receptor, GABAB. Muscimol is a full GABAA agonist and partial G...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

5-(aminomethyl)-3(2H)-isoxazolone

Correlated keywords:

?-aminobutyric acid GABA neurotransmitters GABAA GABAC GABAB agonists benzodiazepines memory neurochemistry neuroscience GABA-A Receptor alpha Subunit GABA Benzodiazepine Receptors GABA A Receptor gamma Subunit GABA A Receptor delta Subunit GABA A Receptor alpha Subunit GABA Benzodiazepine Receptor GABA A Receptor beta Subunit Benzodiazepine-GABA Receptor Benzodiazepine GABA Receptor GABA-A Receptor rho Subunit GABA A Receptor rho Subunit Benzodiazepine Receptors Benzodiazepine Receptor Receptors Muscimol Receptors, Diazepam Muscimol Receptor Diazepam Receptor GABA A Receptors GABA-A Receptor GABA A Receptor

Product Overview:
The amino acid γ-aminobutyric acid (GABA) is an inhibitory neurotransmitter that acts through two families of heteromeric ligand-gated ion channels, GABAA and GABAC and a G protein-coupled receptor, GABAB. Muscimol is a full GABAA agonist and partial GABAC agonist. It binds GABAA on both high- and low-affinity sites (Kd = 10 and 270 nM, respectively), stimulating chloride efflux with an EC50 value of 200 nM.{18163} Benzodiazepines enhance the effects of muscimol via GABAA without altering its binding.{18163,18162} Muscimol activates GABAC receptors with an EC50 value of 1.3 μM.{18156} It also acts as an inhibitor of GABAA uptake and a substrate for the GABA-metabolizing enzyme GABA transaminase.{17741} Muscimol impairs memory formation and retrieval in mice and attenuates airway constriction in guinea pigs in vivo.{18159,18160}

Size	5 mg
Shipping	dry ice
CAS Number	2763-96-4
Molecular Formula	C₄H₆N₂O₂
SMILES	OC1=NOC(CN)=C1
Molecular Weight	114,1
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2932.19
UNSPSC code	12352100

Technical File

MSDS

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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