ONX 0912

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ONX 0912

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Cat No: 16269

Biochemicals - Small Molecule Inhibitors

ONX 0912 is an orally bioavailable proteasome inhibitor.{28242} It potently targets the chymotrypsin-like activity of the 20S proteasome subunits β5 and LMP7 (IC50s = 36 and 82 nM, respectively).{28242} ONX 0912 inhibits the growth of multiple myeloma...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

O-methyl-N-[(2-methyl-5-thiazolyl)carbonyl]-L-seryl-O-methyl-N-[(1S)-2-[(2R)-2-methyl-2-oxiranyl]-2-oxo-1-(phenylmethyl)ethyl]-L-serinamide

Correlated keywords:

1227167-?05-?6 1604802-58-5 ONX0912 orally bioavailable inhibitors CT-L CTL activity 20S proteasome ?5/LMP7 ?5 LMP7 PR047 ubiquitin cancer biochemicals inhibit chymotrypsin multiple myeloma MM

Product Overview:
ONX 0912 is an orally bioavailable proteasome inhibitor.{28242} It potently targets the chymotrypsin-like activity of the 20S proteasome subunits β5 and LMP7 (IC50s = 36 and 82 nM, respectively).{28242} ONX 0912 inhibits the growth of multiple myeloma cells at nanomolar concentrations while not decreasing the viability of normal peripheral blood mononuclear cells at 1 µM.{28245} It blocks the growth of xenografted human multiple myeloma cells in mice when given orally.{28245} ONX 0912 has potential applications in certain types of cancer as well as other diseases that require proteasome activity.{28240,28241,28243,28244}

Size	1 mg
Shipping	dry ice
CAS Number	935888-69-0
Molecular Formula	C₂₅H₃₂N₄O₇S
SMILES	O=C([C@]1(C)OC1)[C@@H](NC([C@H](COC)NC([C@H](COC)NC(C2=CN=C(C)S2)=O)=O)=O)CC3=CC=CC=C3
Molecular Weight	532,6
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2930.90
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.