ML-277

Confirm delete?

ML-277

Zoom

Cat No: 15193

Biochemicals - Ion Channel Modulation

Potassium (K+) channels are categorized by their mode of activation and the number of transmembrane segments.{24547} The voltage-gated six-transmembrane K+ channels include KCNQ1, first recognized for its role in cardiac function and subsequently in he...

This product can only be bought through Cayman Chemical. Please contact us.

Product Overview
Data
Downloads
About Cayman

Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(2R)-N-[4-(4-methoxyphenyl)-2-thiazolyl]-1-[(4-methylphenyl)sulfonyl]-2-piperidinecarboxamide

Correlated keywords:

cardiology ions channels signals transductions activators activates KCNQ1 KCNQ-1 KCNQs 1 one MLs 277 ML-277 ML277 potent Kv7.1 Kv K+ potassiums hERG KCNQ2 KCNQ4 homomultitimeric unsaturated cardiomyocytes rectifier CIDs 53347902 CID-53347902 CID53347902 modes activations transmembrane segments voltage-gated voltage gated six-transmembrane six 6 roles cardiac functions hearing gastrointestinal GI chlorides secretion ML-277 potent KCNQ-2 KCNQ-4 2 4 two four heteromultimeric multimeric homo hetero KCNQ1/KCNE1 KCNQ1-KCNE1 KCNE1 KNCEs models augments delayed currents cultured humans

Product Overview:
Potassium (K+) channels are categorized by their mode of activation and the number of transmembrane segments.{24547} The voltage-gated six-transmembrane K+ channels include KCNQ1, first recognized for its role in cardiac function and subsequently in hearing, gastrointestinal chloride secretion, and other processes.{24547,24548} ML-277 is a potent activator of KCNQ1 channels (EC50 = 260 nM).{24545} The EC50 value of this compound at the related channels KCNQ2, KCNQ4, and hERG exceeds 30 µM.{24545} ML-277 potentiates both homomultimeric KCNQ1 channels and unsaturated heteromultimeric (KCNQ1/KCNE1) channels in model cardiomyocytes and augments delayed rectifier K+ current in cultured human cardiomyocytes.{24546}

Size	1 mg
Shipping	dry ice
CAS Number	1401242-74-7
Molecular Formula	C₂₃H₂₅N₃O₄S₂
SMILES	COC1=CC=C(C2=CSC(NC([C@H]3CCCCN3S(C4=CC=C(C)C=C4)(=O)=O)=O)=N2)C=C1
Molecular Weight	471,6
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2930.90
UNSPSC code	12352100

Technical File

MSDS

Click here to ask for your quote and get 15% off Cayman's products.

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.