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ML-213

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    ML-<wbr/>213
  • ML-<wbr/>213
Cat No: 15185
Biochemicals - Ion Channel Modulation
Cayman

The KCNQ (Kv7) family of voltage-gated potassium (K+) channels consists of five members, KCNQ1-KCNQ5. KCNQ1-KCNQ5 are critical for setting up the excitation threshold of action potentials. KCNQ1 is expressed mainly in cardiac tissue, peripheral epithel...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • N-(2,4,6-trimethylphenyl)-bicyclo[2.2.1]heptane-2-carboxamide
Correlated keywords:
  • Molecular Libraries Initiative SIDs 103073346 SID-103073346 SID103073346 CIDs 3111211 CID-3111211 CID3111211 KCNQ-2 KCNQ-4 2 two 4 four KCNQs KCNQ2 KCNQ4 activators Kvs 7.2 7.4 Kv-7.2 Kv-7.4 Kv7.2 Kv7.4 voltage-gated K+ channels voltage gated potassium MLs 213 ML213 selective
Product Overview:
The KCNQ (Kv7) family of voltage-gated potassium (K+) channels consists of five members, KCNQ1-KCNQ5. KCNQ1-KCNQ5 are critical for setting up the excitation threshold of action potentials. KCNQ1 is expressed mainly in cardiac tissue, peripheral epithelial cells, and smooth muscle cells, while KCNQ2-KCNQ5 are predominantly expressed in the peripheral and central nervous system, including hippocampal cells, cortical cells, and dorsal root ganglion. ML-213 is a selective activator of KCNQ2 (Kv7.2) and KCNQ4 (Kv7.4) channels (EC50s = 230 and 510 nM for KCNQ2 and KCNQ4, respectively) that demonstrates > 80-fold selectivity against other related K+ channels.{24549}
Size 5 mg
Shipping dry ice
CAS Number 489402-47-3
Molecular Formula C17H23NO
SMILES CC1=CC(C)=C(NC(C2CC3CCC2C3)=O)C(C)=C1
Molecular Weight 257,4
Formulation A crystalline solid
Purity ≥98%
Custom Code 2922.19
UNSPSC code 12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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