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XE 991 (hydrochloride)

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    XE 991 (hydro<wbr>chloride)
  • XE 991 (hydro<wbr>chloride)
Cat No: 14582
Biochemicals - Ion Channel Modulation
Cayman

The KCNQ potassium channels are neuronal modulators which combine with other KQT or KCNE channels to form heteromultimers. XE 991 is a blocker of KCNQ channels that potently inhibits KCNQ1 and 2 homomeric channels (IC50 = 0.75 and 0.71 µM, respectively...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone, dihydrochloride
Correlated keywords:
  • 122955-42-4 channels blockers neurosciences Alzheimer’s research XEs XE-991 XE991 991 HCl blocks blocking KCNQ potassium inhibits inhibitions inhibitors KCNQ-1 KCNQ-2 KCNQ1 KCNQ2 1 2 homomeric KCNQ2+3 heteromultimers eag erg elk partners accessory proteins enhances acetylcholine rats brains slices in vivo potency duration actions therapeutics body bodies neuronals modulators KQT KCNE central nervous systems CNS regulations
Product Overview:
The KCNQ potassium channels are neuronal modulators which combine with other KQT or KCNE channels to form heteromultimers. XE 991 is a blocker of KCNQ channels that potently inhibits KCNQ1 and 2 homomeric channels (IC50 = 0.75 and 0.71 µM, respectively) as well as KCNQ2+3 heteromultimers (IC50 = 0.6 µM).{23046} It much less effectively blocks eag, erg, and elk channels. The effectiveness of XE 991 against KCNQ channels depends on partners or accessory proteins.{23045} Through these actions, XE 991 enhances acetylcholine release from rat brain slices (EC50 = 490 nM) and shows good in vivo potency and duration of action, suggesting utility in Alzheimer’s disease therapeutics.{23047} While early studies focused on actions in the central nervous system, XE 991 can be used to explore the roles of KCNQ channels in neuronal regulation throughout the body.{23048}
Size 5 mg
Shipping dry ice
CAS Number 122955-13-9
Molecular Formula C26H20N2O • 2HCl
SMILES O=C1C2=C(C=CC=C2)C(CC3=CC=NC=C3)(CC4=CC=NC=C4)C5=C1C=CC=C5.Cl.Cl
Molecular Weight 449,4
Formulation A crystalline solid
Purity ≥99%
Custom Code 2933.49
UNSPSC code 12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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