SANT 1

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SANT 1

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Cat No: 14933

Biochemicals - Receptor Pharmacology

Smoothened (SMO) is a GPCR-like receptor which, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors.{21774} SANT 1 is a potent inhibitor of hedgehog signaling that acts by directly antagonizing SM...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)-1-piperazinamine

Correlated keywords:

889672-85-9 receptors antagonists cells biology genes regulations neurosciences signal transductions stems cells research cancers smoothened SMOs SANTs SANT1 SANT-1 one 1 potent hedgehog HH antagonism Gli mediated transcriptions GPCR-like GPCR like Patched signaling regulates expressions antagonizing counteracts activations agonists SAG binding binds competes targets inactive cytoplasm primary cilium activated represses repress Gli-mediated

Product Overview:
Smoothened (SMO) is a GPCR-like receptor which, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors.{21774} SANT 1 is a potent inhibitor of hedgehog signaling that acts by directly antagonizing SMO (IC50 = 20 nM).{21771} It counteracts SMO activation by the SMO agonist SAG but only partially competes with SAG binding to SMO.{21771,24191} SANT 1 targets inactive SMO while it is in the cytoplasm, before it relocates to the primary cilium and is activated.{22122} Through antagonism of SMO, SANT 1 represses Gli-mediated transcription in a variety of cell types.{22122,24193}

Size	1 mg
Shipping	dry ice
CAS Number	304909-07-7
Molecular Formula	C₂₃H₂₇N₅
SMILES	CC(N(C1=CC=CC=C1)N=C2C)=C2/C=N/N(CC3)CCN3CC4=CC=CC=C4
Molecular Weight	373,5
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2933.59
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.