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GANT 58

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    GANT 58
  • GANT 58
Cat No: 14193
Biochemicals - Receptor Pharmacology
Cayman

Hedgehog (hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened (Smo). In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the GLI fam...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 4,4’,4’’,4’’’-(2,3,4,5-thiophenetetrayl)tetrakis-pyridine
Correlated keywords:
  • 2,3,4,5-Tetra(4-pyridyl)thiophene 94345-01-4 genes regulations cancers Gli hedgehog HH signalling signaling signals inhbitors inhibits inhibitions transcriptions NSC75503 NSC-75503 NSCs 75503 Ewing sarcoma family of tumors ESFTs GANT-58 GANTs 58 antagonists Gli-1 Gli1 cells smoothened Smo endogenous Sufu proteins development Patched vertebrates zinc-finger factors pathways cancers glioblastomas Gli1-mediated downstream nuclear antiproliferatives anti-proliferatives antitumor anti-tumor
Product Overview:
Hedgehog (hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened (Smo). In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the GLI family. Overactivation of this pathway contributes to certain cancers, including glioblastoma, for which the GLI proteins are named. GANT 58 is a GLI antagonist that inhibits GLI1-mediated transcription (EC50 = 5 μM) in a variety of cell types.{22122,22692,22693} It inhibits the hh signaling pathway downstream of Smo and the endogenous downstream inhibitor Sufu thereby affecting GLI1 nuclear accumulation.{22122} GANT 58 displays antiproliferative and antitumor activity against Ewing sarcoma family of tumor cells.{22692,22693}
Size 5 mg
Shipping dry ice
CAS Number 64048-12-0
Molecular Formula C24H16N4S
SMILES C1(C2=CC=NC=C2)=C(C3=CC=NC=C3)C(C4=CC=NC=C4)=C(C5=CC=NC=C5)S1
Molecular Weight 392,5
Formulation A crystalline solid
Purity ≥98%
Custom Code 2930.90
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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