Irisin Polyclonal Antibody

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Cat No: 14625

Physical exertion and exercise are the primary defenses against obesity, insulin resistance, and diabetes. The transcriptional co-activator peroxisome proliferator-activated receptor C coactivator 1α (PGC-1α), regulates mitochondrial biogenesis and fu...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

Western blots blotting WBs ELISAs enzymes immunoassays immunosorbents EIAs antibodies antiseras antiserums immunoblotting PGC-1a PGC-1alpha PGC-1.alpha. PGC-1? 1a 1alpha 1.alpha. 1? peroxisomes proliferators proliferator-activated activated receptors C coactivators fibronectins types-III types-3 types III 3 FNDC5 domains containing proteins 5 insulin weights losses metabolic metabolisms transcriptional co-activators regulates regulations mitochondrial biogenesis functions obesity resistance diabetes expressions membranes stimulated muscles exercises proteolytically cleaved cleavages secretes secreted secretions hormones peptides Greek Greece goddess Iris white adipose tissues fats WAT brown BAT anti anti-obesity anti-diabetic diseases states mouse mice exogenous levels uncoupling UCP1 thermogenesis heats expenditures physiological responses induced inductions effects increases disorders bacterially expressed

Product Overview:
Physical exertion and exercise are the primary defenses against obesity, insulin resistance, and diabetes. The transcriptional co-activator peroxisome proliferator-activated receptor C coactivator 1α (PGC-1α), regulates mitochondrial biogenesis and function. Expression of the membrane protein fibronectin type III domain-containing protein 5 (FNDC5) is stimulated in muscle by increased expression of the PGC1-α protein in response to exercise. FNDC5 is proteolytically cleaved and secreted as the hormone peptide irisin (named after the Greek goddess messenger Iris). Irisin has been shown to convert white adipose tissue (WAT) to brown adipose tissue (BAT).{20433} An increase in BAT results in anti-obesity and anti-diabetic metabolic states in mice. Exogenous irisin levels in mice leads to higher levels of the uncoupling protein UCP1, which results in an increase in thermogenesis and heat expenditure.{21923} The physiological responses induced by the effects of irisin have the potential to increase weight loss and reduce insulin resistance and metabolic disorder. Cayman’s irisin polyclonal antibody detects a 13 kDa band from bacterially expressed irisin protein (Item No. 11451), and a 32 kDa band from deglycosylated human serum.

Size	1 ea
Shipping	dry ice
Host	Rabbit
Antigen	Synthetic peptide from within human irisin
Application(s)	ELISA and WB
Formulation	Protein A-purified polyclonal antibody
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.