Irisin (human, recombinant)

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Cat No: 11451

Proteins - Enzymes

Physical exertion and exercise are the primary defenses against obesity, insulin resistance, and diabetes. The transcriptional co-activator peroxisome proliferator-activated receptor C coactivator 1α (PGC-1α), regulates mitochondrial biogenesis and fu...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

PGC1-? PGC1? PGC1 ? hormones peptides obesity diabetes insulin resistance Iris brown adipose

Product Overview:
Physical exertion and exercise are the primary defenses against obesity, insulin resistance, and diabetes. The transcriptional co-activator peroxisome proliferator-activated receptor C coactivator 1α (PGC-1α), regulates mitochondrial biogenesis and function.{21133} Expression of the membrane protein Fibronectin type III domain-containing protein 5 (FNDC5) is stimulated in muscle by PGC-1α in response to exercise. FNDC5 is proteolytically cleaved and secreted as the hormone peptide irisin (named after the Greek goddess messenger Iris). Irisin has been shown to convert white adipose fat to brown adipose fat upon physical exertion. Brown adipose fat allows for mitochondrial uncoupling leading to thermogenetic programs and heat expenditure.{20433} The physiological responses induced by the effects of irisin have the potential to increase weight loss and reduce insulin resistance and obesity.

Size	100 µg
Shipping	dry ice
CAS Number	9037-90-5
Formulation	50 mM Tris pH 8.0, 150 mM sodium chloride, and 20% glycerol
Purity	≥90% estimated by SDS-PAGE
Custom Code	3504.00
UNSPSC code	12352204

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.