RGDS Peptide

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RGDS Peptide

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Cat No: 15359

Biochemicals - Peptides

Fibronectin is an extracellular matrix protein which binds other proteins and interacts with cells, serving roles in cell adhesion, migration, and signaling.{5588} Like vitronectin and collagen, fibronectin contains a conserved tripeptide sequence, Arg...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

L-arginylglycyl-L-?-aspartyl-L-serine

Correlated keywords:

1349520-?82-?6 inhibitors inhibits inhibitions vascular diseases peptides infectious signal transduction cells biology fibronectin tetra-peptide tetrapeptide tetra peptides fibrinogen ? a alpha .alpha. von Willebrand factors thrombin bindings binds binders platelets integrins

Product Overview:
Fibronectin is an extracellular matrix protein which binds other proteins and interacts with cells, serving roles in cell adhesion, migration, and signaling.{5588} Like vitronectin and collagen, fibronectin contains a conserved tripeptide sequence, Arg-Gly-Asp (RGD) to associate with integrins on the cell surface.{3775} RGDS peptide is a tetrapeptide found on fibronectin, fibrinogen α, and von Willebrand factor, but not vitronectin or collagen.{25165,25162} RGDS interacts with α5β1 and αVβ3 integrins.{25166} This tetrapeptide interferes with the attachment of cells to fibronectin-coated surfaces (Ki = 0.6 mM).{25165,25162} It also blocks the attachment of certain pathogens to cells.{25163,25164} RGDS peptide inhibits thrombin-induced binding of platelets to fibronectin, fibrinogen α, and von Willebrand factor (IC50 = ~10 μM).{25165,25167,25168} The interaction of RGDS peptide with cell surface integrins alters intracellular signaling in ways that are cell- and stimulus-specific.{25170,25169}

Size	5 mg
Shipping	dry ice
CAS Number	91037-65-9
Molecular Formula	C₁₅H₂₇N₇O₈
SMILES	O=C(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(O)=O)=O)CNC([C@@H](N)CCCNC(N)=N)=O
Molecular Weight	433,4
Formulation	A crystalline solid
Purity	≥95%
Custom Code	3504.00
UNSPSC code	12352204

Technical File

MSDS

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