NU 7026

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NU 7026

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Cat No: 13308

Biochemicals - Kinase Inhibitors

DNA-dependent protein kinase (DNA-PK) binds to strand breaks produced during normal cellular processes or in response to genotoxic stresses, such as ionizing radiation, targeting substrates that facilitate DNA repair. NU 7026 is a cell-permeable, poten...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-(4-morpholinyl)-4H-naphtho[1,2-b]pyran-4-one

Correlated keywords:

DNA-dependent proteins kinase DNA-PK strand breaks ionizing radiation DNA repair inhibitors inhibitis inhibitions PI3K ATM ATR PAPR-1 PARP1 cytotoxicity topoisomerase II leukemia mitoxantrone NU-7026 NU 7026 ataxia telangiectasia mutated Rad3 related Rad3-related Rad 3 Rad-3 DNA-Dependent Protein Kinase

Product Overview:
DNA-dependent protein kinase (DNA-PK) binds to strand breaks produced during normal cellular processes or in response to genotoxic stresses, such as ionizing radiation, targeting substrates that facilitate DNA repair. NU 7026 is a cell-permeable, potent, specific, and ATP-competitive inhibitor of DNA-PK (IC50 = 230 nM).{17273} It poorly inhibits phosphioinositide 3 kinase (IC50 = 13 μM) and is inactive against ataxia telangiectasia mutated kinase, ATR, and poly (ADP-ribose) polymerase.{17273} NU 7026 impairs cellular DNA double strand break repair and decreases survival in cells exposed to ionizing radiation.{17273} It also potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia. For example, it potentiates the growth inhibitory effects of mitoxantrone in K562 cells more than 10-fold.{17274}

Size	5 mg
Shipping	dry ice
CAS Number	154447-35-5
Molecular Formula	C₁₇H₁₅NO₃
SMILES	O=C1C=C(N2CCOCC2)OC3=C4C=CC=CC4=CC=C31
Molecular Weight	281,3
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2933.49
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.