Confirm delete?

Bertin Bioreagent
logo
All categories
Contact Us
You are here :

NU 7441

  • Zoom
    NU 7441
  • NU 7441
Cat No: 14881
Biochemicals - Kinase Inhibitors
Cayman

DNA-dependent protein kinase (DNA-PK) catalyzes nonhomologous end-joining, which is required to repair lethal DNA double-strand breaks. Because cells that are defective in DNA double-strand break repair are highly sensitive to ionizing radiation and to...

More

This product can only be bought through Cayman Chemical. Please contact us.

Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 8-(4-dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one
Correlated keywords:
  • inhibitors inhibits inhibitions DNA dependent DNA-dependent proteins kinases DNAPK PK DNA-PK nonhomologous end-joining end joining endjoiing double-strand double strands breaks repairs ionizing radiation topoisomerase II cancers resistance NU7441 NU-7441 Nus 7441 selective PI3K PIKK mTOR ATM ATR ataxia-telangiectasia ataxia mutated telangiectasia ions ionizing radiation etoposide humans colon cancers cells lines in vitro potentiates tumors in vivo Ku57788 Kus 57788 intracellular signaling signals
Product Overview:
DNA-dependent protein kinase (DNA-PK) catalyzes nonhomologous end-joining, which is required to repair lethal DNA double-strand breaks. Because cells that are defective in DNA double-strand break repair are highly sensitive to ionizing radiation and topoisomerase II poisons, modulating DNA-PK is one strategy to defer cancer cell resistance to radiation or chemotherapeutic treatments.{17273} NU 7441 is a selective DNA-PK inhibitor with an IC50 value of 14 nM.{23765} It inhibits other members of the PI3K-related kinase family, including mTOR, PI3K, ataxia telangiectasia mutated (ATM), and ataxia telangiectasia and Rad3 related (ATR) with IC50 values of 1.7, 5, >100, and >100 μM, respectively.{23765} NU 7441 has been shown to increase the cytotoxicity of ionizing radiation and etoposide (Item No. 12092) in human colon cancer cell lines in vitro and to potentiate the effects of etoposide in mice bearing human colon cancer xenograft tumors in vivo.{23764}
Size 1 mg
Shipping dry ice
CAS Number 503468-95-9
Molecular Formula C25H19NO3S
SMILES O=C(C=C(N1CCOCC1)O2)C3=C2C(C4=CC=CC5=C4SC6=C5C=CC=C6)=CC=C3
Molecular Weight 413,5
Formulation A crystalline solid
Purity ≥98%
Custom Code 2930.90
UNSPSC code 12352100

Click here to ask for your quote and get 15% off Cayman's products.

 

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

/ We also advise you

Cross selling for this product : NU 7441 There are 10 products.

Search