NVP-BEZ235

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NVP-BEZ235

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Cat No: 10565

Biochemicals - Kinase Inhibitors

NVP-BEZ235 is a dual inhibitor of class I PI3Ks (IC50s = 4, 75, 7, and 5 nM, for p110α, - β, -δ, and -γ, respectively) and mTOR (IC50 = 20 nM).{18570} It is selective for these enzymes over a panel of kinases (IC50s = >10 µM for all). NVP-BEZ235 (0.1 ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4-[2,3-dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo[4,5-c]quinolin-1-yl]-?,?-dimethyl-benzeneacetonitrile

Correlated keywords:

1028385-32-1 1146702-52-4 NVPBEZ235 p110? p110? p110? MCF7 MDAMB468 MDAMB MB468 MB361 SKBR3 SKBR-3 BR3 U87 MG BEZ 23 235 BEZ23 BEZ235 NVP NVPBE RTB 101 RTB101

Product Overview:
NVP-BEZ235 is a dual inhibitor of class I PI3Ks (IC50s = 4, 75, 7, and 5 nM, for p110α, - β, -δ, and -γ, respectively) and mTOR (IC50 = 20 nM).{18570} It is selective for these enzymes over a panel of kinases (IC50s = >10 µM for all). NVP-BEZ235 (0.1 or 1 µM) inhibits proliferation of, and induces apoptosis in, MCF-7, MDA-MB-468, SK-BR-3, and MDA-MB-361 breast cancer cells.{18572} It reduces tumor growth in a U87MG mouse xenograft model when administered at a doses of 25, 35, or 45 mg/kg.{18570}

Size	25 mg
Shipping	dry ice
CAS Number	915019-65-7
Molecular Formula	C₃₀H₂₃N₅O
SMILES	CC(C#N)(C)C(C=C1)=CC=C1N(C(N2C)=O)C3=C2C=NC4=CC=C(C5=CC(C=CC=C6)=C6N=C5)C=C43
Molecular Weight	469,5
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2914.69
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.