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trans-Resveratrol

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    <em>trans</em>-<wbr/>Resveratrol
  • <em>trans</em>-<wbr/>Resveratrol
Cat No: 70675
Cayman
€25.00
Price is excluding VAT and does not include packaging neither shipping

A polyphenolic phytoalexin found in a variety of plants; has anti-inflammatory, antioxidant, and anticancer activities; inhibits the cyclooxygenase and hydroperoxidase activities of COX-1 (EC50s = 15 and 3.7 μM, respectively), but not COX-2 (EC50s = >1...

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Territorial Availability: Available through Bertin Technologies only in Europe
Synonyms:
  • 5-[(1E)-2-(4-hydroxyphenyl)ethenyl]-1,3-benzenediol
  • (E)-Resveratrol
Correlated keywords:
  • selective
  • cyclooxygenases
  • inhibitors
  • COX-1
  • PGHS-1
  • COX1
  • PGHS1
  • prostaglandins
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Product Overview:
A polyphenolic phytoalexin found in a variety of plants; has anti-inflammatory, antioxidant, and anticancer activities; inhibits the cyclooxygenase and hydroperoxidase activities of COX-1 (EC50s = 15 and 3.7 μM, respectively), but not COX-2 (EC50s = >100 μM and 85 μM, respectively); inhibits carrageenan-induced paw edema in mice at 3 and 8 mg/kg; inhibits free radical formation in HL-60 human promyelocytic leukemia cells induced by TPA (EC50 = 27 μM); reduces both the incidence and number of tumors in a two-stage mouse model of skin cancer induced by TPA and DMBA at 1-25 μmol; activates SIRT1 by 8-fold in vitro at 200 μM; inhibits ERK1, JNK1, Src, PKCα, aromatase/CYP19, and DNA polymerases α and δ (IC50s = 37, 50, 20, in vitro and/or ex vivo; prolongs lifespan in model organisms including C. elegans, D. melanogaster, and mice
trans-Resveratrol is a polyphenolic phytoalexin found in a variety of plants, including grapes, that has anti-inflammatory, antioxidant, and anticancer activities. It inhibits the cyclooxygenase and hydroperoxidase activities of COX-1 (EC50s = 15 and 3.7 μM, respectively), but not COX-2 (EC50s = >100 μM and 85 μM, respectively). trans-Resveratrol (3 and 8 mg/kg) inhibits carrageenan-induced paw edema in mice. It inhibits free radical formation in HL-60 human promyelocytic leukemia cells induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014; EC50 = 27 μM). trans-Resveratrol (1-25 μmol) reduces both the incidence and number of tumors in a two-stage mouse model of skin cancer induced by TPA and 7,12-dimethyl-benz[a]anthracene (DMBA). trans-Resveratrol (200 μM) also activates sirtuin 1 (SIRT1) by 8-fold in vitro and inhibits a variety of targets including ERK1, JNK1, Src, PKCα, aromatase/CYP19, and DNA polymerases α and δ (IC50s = 37, 50, 20, in vitro and/or ex vivo. It prolongs lifespan in model organisms including C. elegan, D. melanogaster, and mice.
Size 50 mg
Shipping wet ice
Stability Store at -20 degrees; shelf life 730 days maximum after production
CAS Number 501-36-0
Molecular Formula C14H12O3
SMILES Oc1ccc(cc1)\C=C/c1cc(O)cc(O)c1
Molecular Weight 228.2
Formulation A crystalline solid
Purity ≥98%
Custom Code 2907299000
UNSPSC code 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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