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  • <em>trans</em>-<wbr/>Resveratrol
Cat No: 70675
Biochemicals - Kinase Inhibitors

trans-Resveratrol is a polyphenol that has been found in grapes and has diverse biological activities.{3491,43362} It inhibits the cyclooxygenase and hydroperoxidase activities of COX-1 (EC50s = 15 and 3.7 μM, respectively) but not COX-2 (EC50s = >100...


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Territorial Availability: Available through Bertin Technologies only in France
  • 5-[(1E)-2-(4-hydroxyphenyl)ethenyl]-1,3-benzenediol
Correlated keywords:
  • Trihydroxystilbene Trihydroxy-stilbene Stilbenetriol Trihydroxy-trans-stilbene Biofort CA-1201 CA1201 Cuspidatin Melinjo Resveratrol 20 Polygonin Regu-Fade P-5 P5 Resvida SRT-501 501M 501-M SRT501 SRT501M Vineatrol 20M 20-M Cyclo-oxygenase hydro-peroxidase COX1 COX2 SIRT-1 ERK1 JNK-1 PKC-? CYP-19 HL60 HSV1 HSV2 Caenorhabditis Drosophila antiinflammatory anti-viral
Product Overview:
trans-Resveratrol is a polyphenol that has been found in grapes and has diverse biological activities.{3491,43362} It inhibits the cyclooxygenase and hydroperoxidase activities of COX-1 (EC50s = 15 and 3.7 μM, respectively) but not COX-2 (EC50s = >100 μM and 85 μM, respectively).{3491} trans-Resveratrol (200 μM) also activates sirtuin 1 (SIRT1), as well as inhibits a variety of targets including ERK1, JNK1, Src, PKCα, aromatase/CYP19, and DNA polymerases α and δ (IC50s = 37, 50, 20, in vitro.{13296,43362} It inhibits free radical formation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in HL-60 cells and reduces the tumor incidence and number of tumors in a two-stage mouse model of skin cancer induced by TPA and 7,12-dimethyl-benz[a]anthracene (DMBA). trans-Resveratrol (3 and 8 mg/kg) inhibits carrageenan-induced paw edema in mice. Intravaginal administration of trans-resveratrol (12.5% v/v) inhibits herpes simplex virus 1 (HSV-1) and HSV-2 replication and delays the development of extravaginal disease in mouse models of vaginal HSV infection.{60119} It also prolongs lifespan in model organisms including C. elegans, D. melanogaster, and mice.{43362}
Size 50 mg
Shipping dry ice
CAS Number 501-36-0
Molecular Formula C14H12O3
SMILES Oc1ccc(cc1)\C=C/c1cc(O)cc(O)c1
Molecular Weight 228,2
Formulation A crystalline solid
Purity ≥98%
Custom Code 2907.29
UNSPSC code 12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

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