MeCP2 (human recombinant; methyl binding domain aa 77-166)

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Cat No: 11287

Proteins - More Proteins

DNA methylation occurs mainly at the 5’-position of cytosine rings (5-methylcytosine (5mC)). The 5mC bases are found largely in genomic regions with a high frequency of cytosines and guanines, called CpG islands. Methyl-CpG binding protein 2 (MeCP2) s...

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Correlated keywords:

Methyl CpG binding domains genes expressions DNA chromatin MBD epigenetics CpG islands MBDs 5-methylcytosine 5mC neurological Rett Syndrome MeCp-2 protein

Product Overview:
DNA methylation occurs mainly at the 5’-position of cytosine rings (5-methylcytosine (5mC)). The 5mC bases are found largely in genomic regions with a high frequency of cytosines and guanines, called CpG islands. Methyl-CpG binding protein 2 (MeCP2) specifically binds to methylated promoters on CpG islands and mediates gene silencing by recruiting corepressor complexes.{20308} The Methyl-CpG Binding Domain (MBD) protein family consists of five members: MeCP2, MBD1, MBD2, MBD3 and MBD4.{20692,20693,17996} The sequence similarity between the MBD proteins is limited to the MBD domains.{20691} In vitro work suggests high affinity binding of MeCP2 is facilitated by DNA fragments containing A/T bases ([A/T]≥4) adjacent to the methyl-CpG.{20309} Mutations in the MeCP2 gene have been linked to the X-linked neurological disorder, Rett Syndrome.{20806}

Size	100 µg
Shipping	dry ice
Formulation	50 mM Tris, pH 7.5, with 500 mM sodium chloride, 5% glycerol, and 5 mM ?-mercaptoethanol
Purity	≥95%
Custom Code	3504.00
UNSPSC code	12352204

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