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MeCP2 (human recombinant; methyl binding domain aa 77-166)

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    MeCP2 (human recombinant; methyl binding domain aa 77-<wbr/>166)
  • MeCP2 (human recombinant; methyl binding domain aa 77-<wbr/>166)
Cat No: 11287
Proteins - More Proteins
Cayman
€376.00
Price is excluding VAT and does not include packaging neither shipping

DNA methylation occurs mainly at the 5’-position of cytosine rings (5-methylcytosine (5mC)). The 5mC bases are found largely in genomic regions with a high frequency of cytosines and guanines, called CpG islands. Methyl-CpG binding protein 2 (MeCP2) s...

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: 100 µg

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Territorial Availability: Available through Bertin Pharma only in Europe
Correlated keywords:
  • Methyl CpG binding domains genes expressions DNA chromatin MBD epigenetics CpG islands MBDs 5-methylcytosine 5mC neurological Rett Syndrome MeCp-2 protein
Product Overview:
DNA methylation occurs mainly at the 5’-position of cytosine rings (5-methylcytosine (5mC)). The 5mC bases are found largely in genomic regions with a high frequency of cytosines and guanines, called CpG islands. Methyl-CpG binding protein 2 (MeCP2) specifically binds to methylated promoters on CpG islands and mediates gene silencing by recruiting corepressor complexes.{20308} The Methyl-CpG Binding Domain (MBD) protein family consists of five members: MeCP2, MBD1, MBD2, MBD3 and MBD4.{20692,20693,17996} The sequence similarity between the MBD proteins is limited to the MBD domains.{20691} In vitro work suggests high affinity binding of MeCP2 is facilitated by DNA fragments containing A/T bases ([A/T]≥4) adjacent to the methyl-CpG.{20309} Mutations in the MeCP2 gene have been linked to the X-linked neurological disorder, Rett Syndrome.{20806}
Size 100 µg
Shipping dry ice
Stability Store at -80 degrees; shelf life 365 days
Formulation 50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5% glycerol, and 5 mM β-mercaptoethanol
Purity ≥95%
Custom Code 3504.00
UNSPSC code 12352204

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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