MBD2 (human recombinant; methyl binding domain aa 150-220)

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Cat No: 11286

Proteins - More Proteins

DNA methylation occurs mainly at the 5’-position of cytosine rings (5-methylcytosine (5mC)). The 5mC bases are found largely in genomic regions with a high frequency of cytosines and guanines, called CpG islands. Methyl-CpG binding domain 2 (MBD2) pro...

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Correlated keywords:

Methyl CpG binding domains genes expression DNA chromatin MBD epigenetics CpG islands methylation MBDs 5-methylcytosine 5mC breast cancer tumors

Product Overview:
DNA methylation occurs mainly at the 5’-position of cytosine rings (5-methylcytosine (5mC)). The 5mC bases are found largely in genomic regions with a high frequency of cytosines and guanines, called CpG islands. Methyl-CpG binding domain 2 (MBD2) protein specifically binds to methylated promoters on CpG islands. The MBD protein family consists of five members: MeCP2, MBD1, MBD2, MBD3, and MBD4.{20692,20693,17996} The sequence similarity between the MBD proteins is limited to the MBD domains.{20691} MBD2 binding to 5mC facilitates the recruitment of chromatin remodeling and transcriptional repressor complexes, which results in a repressive chromatin state.{20694,20691} MBD2 has been implicated in breast cancer progression. Silencing of MBD2 protein expression was found to be sufficient to initiate and maintain tumor suppressor gene transcription.{19794}

Size	100 µg
Shipping	dry ice
Formulation	50 mM Tris, pH 7.5, with 500 mM sodium chloride, 5% glycerol, and 5 mM ?-mercaptoethanol
Purity	≥95%
Custom Code	3504.00
UNSPSC code	12352204

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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