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  • (–)-<wbr/>Blebbistatin
Cat No: 13013
Biochemicals - Small Molecule Inhibitors

(–)-Blebbistatin is a selective cell-permeable inhibitor of non-muscle myosin II ATPases and the active enantiomer of (+)-blebbistatin (Item No. 13165).{16452,17037} It rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-m...


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Territorial Availability: Available through Bertin Technologies only in France
  • 1,2,3,3a-tetrahydro-3aS-hydroxy-6-methyl-1-phenyl-4H-Pyrrolo[2,3-b]quinolin-4-one
Correlated keywords:
  • myosin bleb migration chemotaxis cytokinesis division growth UV (-)-(S)-Blebbistatin
Product Overview:
(–)-Blebbistatin is a selective cell-permeable inhibitor of non-muscle myosin II ATPases and the active enantiomer of (+)-blebbistatin (Item No. 13165).{16452,17037} It rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50s = 0.5-5 µM), while poorly inhibiting smooth muscle myosin (IC50 = 80 µM).{17036} Through these effects, it blocks apoptosis-related bleb formation, directed cell migration, and cytokinesis in vertebrate cells. However, prolonged exposure to blue light (450-490 nm) results in degradation of blebbistatin to an inactive product via cytotoxic intermediates, which may be problematic for its use in fluorescent live cell imaging applications.{17038,24037} (S)-nitro-Blebbistatin (Item No. 13186) is a more stable form of (–)-blebbistatin.{16725} The addition of a nitro group stabilizes the molecule to circumvent its degradation by prolonged blue light exposure. (S)-nitro-Blebbistatin has the same stereochemistry as the active (–)-blebbistatin enantiomer.
Size 1 mg
Shipping dry ice
CAS Number 856925-71-8
Molecular Formula C18H16N2O2
SMILES CC1=CC2C(C=C1)N=C1N(CC[C@@]1(O)C2=O)c1ccccc1
Molecular Weight 292,3
Formulation A crystalline solid
Purity ≥98%
Custom Code 2914.69
UNSPSC code 12352100

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