(S)-3'-amino Blebbistatin

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Cat No: 24170

Biochemicals - Small Molecule Inhibitors

(S)-3’-amino Blebbistatin is a more stable and less phototoxic form of (–)-blebbistatin (Item No. 13013), which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases.{16452,17037} (–)-Blebbistatin rapidly and reversibly inhibits Mg-A...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(3aS)-1-(3-aminophenyl)-1,2,3,3a-tetrahydro-3a-hydroxy-6-methyl-4H-pyrrolo[2,3-b]quinolin-4-one

Correlated keywords:

nonmuscle MgATPase

Product Overview:
(S)-3’-amino Blebbistatin is a more stable and less phototoxic form of (–)-blebbistatin (Item No. 13013), which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases.{16452,17037} (–)-Blebbistatin rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50s = 0.5-5 µM), while poorly inhibiting smooth muscle myosin (IC50 = 80 µM).{17036} Through these effects, it blocks apoptosis-related bleb formation, directed cell migration, and cytokinesis in vertebrate cells. However, prolonged exposure to blue light (450-490 nm) results in degradation of blebbistatin to an inactive product via cytotoxic intermediates, which may be problematic for its use in fluorescent live cell imaging applications.{17038,24037} The addition of a 3’-amino group decreases the inherent fluorescence while retaining the activity of (–)-blebbistatin.{40574} (S)-3'-amino Blebbistatin has the same stereochemistry as the active (–)-blebbistatin enantiomer.

Size	500 µg
Shipping	dry ice
CAS Number	2097141-18-7
Molecular Formula	C₁₈H₁₇N₃O₂
SMILES	O=C1[C@@]2(O)C(N(C3=CC=CC(N)=C3)CC2)=NC4=C1C=C(C)C=C4
Molecular Weight	307,3
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2921.19
UNSPSC code	12352100

Technical File

MSDS

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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