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(+)-Blebbistatin

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    (+)-<wbr/>Blebbistatin
  • (+)-<wbr/>Blebbistatin
Cat No: 13165
Biochemicals - Small Molecule Inhibitors
Cayman

(+)-Blebbistatin is the inactive enantiomer of (–)-blebbistatin (Item No. 13013), which is a selective inhibitor of non-muscle myosin II ATPases.{16452,17037} Prolonged exposure to blue light (450-490 nm) results in degradation of blebbistatin to an i...

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This product can only be bought through Cayman Chemical. Please contact us.

Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 1,2,3,3a-tetrahydro-3aR-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one
Correlated keywords:
  • inhibitors muscles myosin ATPase smooth muscle bleb apoptosis cell migration chemotaxis cytokinesis cells division growth UV light (+)-(R)-Blebbistatin inhibition inhibited
Product Overview:
(+)-Blebbistatin is the inactive enantiomer of (–)-blebbistatin (Item No. 13013), which is a selective inhibitor of non-muscle myosin II ATPases.{16452,17037} Prolonged exposure to blue light (450-490 nm) results in degradation of blebbistatin to an inactive product via cytotoxic intermediates, which may be problematic for its use in fluorescent live cell imaging applications.{17038,24037} (R)-nitro-Blebbistatin (Item No. 9001935) is a more stable form of (+)-blebbistatin.{16725} The addition of a nitro group stabilizes the molecule to circumvent its degradation by prolonged blue light exposure. (R)-nitro-Blebbistatin has the same stereochemistry as the inactive (+)-blebbistatin enantiomer.
Size 1 mg
Shipping dry ice
CAS Number 1177356-70-5
Molecular Formula C18H16N2O2
SMILES Cc1ccc2N=C3N(CC[C@@]3(O)C(=O)c2c1)c1ccccc1
Molecular Weight 292,3
Formulation A crystalline solid
Purity ≥98%
Custom Code 2914.69
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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