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SREBP-1 Transcription Factor Assay Kit

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    SREBP-<wbr/>1 Transcription Factor Assay Kit
  • SREBP-<wbr/>1 Transcription Factor Assay Kit
Cat No: 10010854
Assay Kits - Elisa

Three known isoforms of SREBP (sterol regulatory element binding protein) transcription factors have been characterized: SREBP-1a, SREBP-1c, and SREBP-2. SREBP-1c acts primarily to activate genes required for fatty acid synthesis, such as acetyl-CoA c...

: 96 wells

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Territorial Availability: Available through Bertin Technologies only in France
Correlated keywords:
  • tf atherosclerosis SREBPs sterols regulatory element binding proteins factors basic helix-loop-helix-leucine zipper family expression regulate synthesis regulation uptake cholesterol fatty acids triglycerides phospholipids adipocyte differentiation insulin-dependent genes SREBP-1a membrane-bound rough ER endoplasmic reticulum cleavage activating SREBP-Scap Golgi proteolytic two-step cleavage S1P S2P NH2 -terminal active domain nuclear localization signal importin nucleus upregulating genes fatty acids lipogenic enzymes acetyl CoA coenzymes A carboxylases synthases long chain elongases glucose glucokinases glycolysis diseases obesity diabetes mellitus insulin resistance non-alcoholic liver non-radioactive sensitve sensitivity detects detecting double stranded dsDNA extracts ELISA EMSA humans rats mouse mice murine SREBP1C SREBP 1c assays
Product Overview:
Three known isoforms of SREBP (sterol regulatory element binding protein) transcription factors have been characterized: SREBP-1a, SREBP-1c, and SREBP-2. SREBP-1c acts primarily to activate genes required for fatty acid synthesis, such as acetyl-CoA carboxylase, fatty acid synthase, and long chain fatty acid elongase. In addition, SREBP-1c may also contribute to the regulation of glucose uptake and synthesis through induction of glucokinase. SREBP-1c has important clinical implications in the treatment of many diseases including obesity, diabetes mellitus, insulin resistance, and non-alcoholic fatty liver disease (NAFLD). Cayman’s SREBP-1 Transcription Factor Assay is a non-radioactive, sensitive method for detecting specific transcription factor DNA binding activity. SREBP-1 contained in nuclear extracts and whole cell lysates binds to a dsDNA SREBP response element immobilized to the wells of a 96-well plate. SREBP-1 is detected by addition of a specific primary antibody directed against SREBP-1. A secondary antibody conjugated to HRP is used to provide a sensitive colorimetric readout at 450 nm.
Size 96 wells
Shipping dry ice
Custom Code 3822.19
UNSPSC code 41116104

Horton, J.D., Shah, N.A., Warrington, J.A., et al. Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes. Proc Natl Acad Sci USA 100(21) 12027-12032 (2003).

Shimano, H. SREBP-1c a

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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