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Cat No: 11041
Biochemicals - Natural Products

Sterol regulatory element binding protein 2 (SREBP-2) regulates cholesterol synthesis by activating the transcription of genes for HMG-CoA reductase and other enzymes of the cholesterol synthetic pathway.{13851,13853} When cellular sterol levels are hi...


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Territorial Availability: Available through Bertin Technologies only in France
  • lup-20(29)-ene-3?,28-diol
Correlated keywords:
  • 1406-58-2 1192133-66-6 betuline betulinic alcohol betulinol betulol NSC4644 NSC-4644 SREBP-2 cholesterol nuclear transcription factors natural products metabolic diseases anti-cancers atherosclerosis triterpene betulinic acids pentacyclic birch trees inhibits inhibitors inhibitions SREBPs SREBP2 SCAP-Insig binding binds ER lipids western-type atherosclerotic plaques LDLR Jurkat A549 carcinoma cells HeLa
Product Overview:
Sterol regulatory element binding protein 2 (SREBP-2) regulates cholesterol synthesis by activating the transcription of genes for HMG-CoA reductase and other enzymes of the cholesterol synthetic pathway.{13851,13853} When cellular sterol levels are high, SREBP is bound by SCAP and Insig to ER membranes as a glycosylated precursor protein. Upon cholesterol depletion, the protein is cleaved to its active form and translocated into the nucleus to stimulate transcription of genes involved in the uptake and synthesis of cholesterol.{13148} Betulin, the precursor of betulinic acid, is a pentacyclic triterpene found in the bark of birch trees. Betulin inhibits the SREBP-driven pathway of cholesterol and fatty acid biosynthesis by promoting SCAP–Insig binding which prevents the activation and release of SREBP-2 from the ER.{19894} At 15-30 mg/kg/day, betulin has been shown to decrease lipid levels and increase insulin sensitivity in mice fed a western-type diet.{19894} In an atherosclerosis disease model, 30 mg/kg/day betulin can reduce the size and improve the stability of atherosclerotic plaques in LDLR-knockout mice.{19894} At 2.5-5 μg/ml betulin, in combination with cholesterol, demonstrates anticancer effects by inducing apoptosis in Jurkat cells, A549 lung carcinoma cells, and HeLa cervical carcinoma cells.{22046}
Size 250 mg
Shipping dry ice
CAS Number 473-98-3
Molecular Formula C30H50O2
SMILES O[C@H]1CC[C@@]2(C)[C@](CC[C@]3(C)[C@]2([H])CC[C@@]4([H])[C@]3(CC[C@]5(CO)[C@]4([H])[C@H](C(C)=C)CC5)C)([H])C1(C)C
Molecular Weight 442,7
Formulation A crystalline solid
Purity ≥98%
Custom Code 2907.19
UNSPSC code 12352100

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