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MitoCheck® Complex II Activity Assay Kit

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    MitoCheck<sup>®</sup> Complex II Activity Assay Kit
  • MitoCheck<sup>®</sup> Complex II Activity Assay Kit
Cat No: 700940
Assay Kits - Colorimetric Assays

Complex II (succinate dehydrogenase/co-enzyme Q reductase) is one of the major sites of electron entry into the mitochondrial electron transport chain (ETC). Complex II catalyzes the oxidation of succinate to fumarate, and in the process reduces ubiqu...

: 96 wells

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Territorial Availability: Available through Bertin Technologies only in France
Correlated keywords:
  • kits assays measures measurements two 2 succinates dehydrogenases dehydrogenase/co-enzyme Q CoQ10 reductases sites electrons entry mitochondrial mitochondrias transports chains ETCs catalyzes oxidations fumarates reduces reductions ubiquinones ubiquinol QH2 oxygens O2 terminal steps respirations dysfunctions inhibits inhibitors inhibitions oncogenesis cancers inhibitory effects dehydrogenases atpenin A5 2-Thenoyltrifluoroacetone TTFA malonates isolates isolations DCPIP complexes rotenone antimycin A potassium cyanides KCN
Product Overview:
Complex II (succinate dehydrogenase/co-enzyme Q reductase) is one of the major sites of electron entry into the mitochondrial electron transport chain (ETC). Complex II catalyzes the oxidation of succinate to fumarate, and in the process reduces ubiquinone (Q) to ubiquinol (QH2). Ultimately, oxidation of succinate will lead to reduction of O2, the terminal step in mitochondrial respiration. Cayman’s MitoCheck® Complex II Activity Assay allows for the activity of complex II to be determined without the need to isolate mitochondria or pre-incubate with antibodies. As complex II oxidizes succinate, electrons are passed to an analog of ubiquinone and then on to DCPIP, which, when oxidized, absorbs in the 600 nm range. The absorbance of DCPIP will decrease upon reduction. Thus, Complex II activity is measured as a decrease in absorbance at 600 nm over time. For the use of this kit with other types of tissue mitochondria, please see Cayman's MitoCheck® Mitochondrial (Tissue) Isolation Kit (Item No. 701010).
Size 96 wells
Shipping dry ice
Custom Code 3822.19
UNSPSC code 41116104

King, A., Selak, M.A., and Gottlieb, E. Succinate dehydrogenase and fumarate hydratase: Linking mitochondrial dysfunction and cancer. Oncogene 25(34) 4675-4682 (2006).

Pollard, P.J., Wortham, N.C., and Tomlinson, I.P. The TCA cycle and tumorigenesis: The

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