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11-dehydro Thromboxane B2 ELISA Kit - Monoclonal

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    11-<wbr/>dehydro Thromboxane B<sub>2</sub> ELISA Kit -<wbr/> Monoclonal
  • 11-<wbr/>dehydro Thromboxane B<sub>2</sub> ELISA Kit -<wbr/> Monoclonal
Cat No: 519510
Assay Kits - Elisa
Price is excluding VAT and does not include packaging neither shipping

Thromboxane A2 (TXA2), produced from arachidonic acid, causes irreversible platelet aggregation, vascular, and bronchial smooth muscle contraction. TXA2 is rapidly hydrolyzed non-enzymatically to form TXB2. However, most of the TXB2 measured in the pl...


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Territorial Availability: Available through Bertin Technologies only in Europe
Correlated keywords:
  • 11-dehydro-TXB2 enzymes immunoassays EIAs ELISAs kits assays measures measurements competitive quantification thromboxanes A2 TXA2 arachidonic acids platelets aggregation vascular bronchial smooth muscles hydrolyzed plasma urine ex vivo activation intra-renal production metabolites kidneys metabolized dehydrogenases enzymes cytosolic aldehydes peroxisomes peroxisomal b-oxidations beta-oxidations .beta.-oxidations β-oxidations infusions study studies circulating half-life t1/2 2,3-dinor 11-dehydro-2,3-dinor gas chromatography mass spectrometry GC/MS dosing doses aspirin acetylsalicylic acid NSAIDS nonsteroidal anti-inflammatory drugs smokers levels non-enzymatically 519501 (Monoclonal)
Product Overview:
Thromboxane A2 (TXA2), produced from arachidonic acid, causes irreversible platelet aggregation, vascular, and bronchial smooth muscle contraction. TXA2 is rapidly hydrolyzed non-enzymatically to form TXB2. However, most of the TXB2 measured in the plasma or urine of healthy individuals is due to ex vivo platelet activation or intra-renal production, and normal concentrations of circulating TXB2 are extremely low (1-2 pg/ml) and highly transient (t½ = 5-7 minutes). 11-dehydro TXB2 is a metabolite of TXB2 (not formed by platelets or the kidney) with a circulating half-life (t½) of 45 minutes. Its measurement in plasma or urine will give a time-integrated indication of TXA2 production and is recommended to estimate TXA2 levels to circumvent measurement complications associated with TXB2. Cayman’s 11-dehydro TXB2 ELISA Kit is a competitive assay that can be used for quantification of 11-dehydro TXB2 in urine and other sample matrices. Normal plasma levels of 11-dehydro TXB2 (1-2 pg/ml) are below the detection limit of this assay (16 pg/ml), so plasma samples must be purified and concentrated prior to analysis. Urine samples should be diluted appropriately before assaying. There is evidence suggesting that 11-dehydro TXB2 can be formed non-enzymatically following platelet activation, so it is important to process plasma samples quickly to prevent artifactual formation of 11-dehydro TXB2. The assay has a range from 15.6-2,000 pg/ml and a sensitivity (80% B/B0) of approximately 34 pg/ml.
Size 96 strip wells
Shipping dry ice
Custom Code 3822.00
UNSPSC code 41116104

Hamberg, M., Svensson, J., and Samuelsson, B. Thromboxanes: A new group of biologically active compounds derived from prostaglandin endoperoxides. Proc Natl Acad Sci USA 72 2994-2998 (1975).

Fauler, J., Tsikas, D., Mayatepek, E., et al. Impaired degradati

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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