Thromboxane B2 ELISA Kit

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Thromboxane B₂ ELISA Kit

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Cat No: 501020

Assay Kits - Elisa

Thromboxane A2 (TXA2) is produced from arachidonic acid by many cells and causes irreversible platelet aggregation and contraction of vascular and bronchial smooth muscle.{487,6062,6063} Like most lipid mediators, TXA2 is not a circulating hormone. It...

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Correlated keywords:

kits assays measures measurements ELISAs EIAs enzymes immunoassays immunosorbents thromboxanes A2 TXs TXA2 B2 TXB2 arachidonic acids cells irreversible platelets aggregations contractions vascular bronchial smooth muscles lipids mediators circulating hormones responses local stimuli stimulus effects hydrolyzed hydrolysis non-enzymatically forms forming metabolized metabolizes urine urinary metabolites kidneys renal whole animal experiments experimental models plasma ex vivo activations intra-renal intra productions 11-dehydro in vivo perfusates lavage samples tissues cells cultures competitive quantifies quantifications media medium matrix matrices 519031

Product Overview:
Thromboxane A2 (TXA2) is produced from arachidonic acid by many cells and causes irreversible platelet aggregation and contraction of vascular and bronchial smooth muscle.{487,6062,6063} Like most lipid mediators, TXA2 is not a circulating hormone. It is formed in response to local stimuli and exerts its effects within a short distance of its biosynthesis. TXA2 is rapidly hydrolyzed non-enzymatically to form TXB2, which is then quickly metabolized (t½ = 5-7 minutes) to urinary metabolites for clearance by the kidneys.{868} Because of the transient nature of this compound it is difficult to accurately measure circulating levels in whole animal experimental models. In fact, it has been shown that plasma and urine levels of TXB2 are primarily due to ex vivo platelet activation and intra-renal production, respectively.{868,6304,310} Therefore, measurement of TXB2 metabolites, such as 11-dehydro TXB2 (Item No. 519510), in urine and plasma may give more accurate estimates of in vivo TXA2 production.{518,1410,2571} TXB2 measurement is better suited for samples that are unlikely to undergo extensive metabolism such as perfusates, lavage samples, tissue/cell culture, etc.

Size	96 strip wells
Shipping	dry ice
Custom Code	3822.19
UNSPSC code	41116104

Ellis, E.F., Oelz, O., Roberts, L.J., et al. Coronary arterial smooth muscle contraction by a substance released from platelets: Evidence that it is thromboxane A₂. Science 193 1135-1137 (1976).

Maxey, K.M., Maddipati, K.R., and Birkmeier, J. I

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.