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6-
keto Prostaglandin F1? ELISA Kit
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Cat No: 515211
Assay Kits
- Elisa
Prostacyclin (Prostaglandin I2; PGI2) is formed from arachidonic acid primarily by the vascular endothelium and renal cortex.{502,7044} It is a potent vasodilator and inhibitor of platelet aggregation.{7044} PGI2 is non-enzymatically hydrated to 6-ket...
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Territorial Availability: Available through Bertin Technologies only in France
Correlated keywords:
- solid plates 6-keto-PGF1alpha 6-keto-PGF1.alpha. prostaglandins measures kits eias atherosclerosis enzyme immunoassays ELISAs 6-keto Prostaglandin F1.alpha. EIA Kit assays
Product Overview:
Prostacyclin (Prostaglandin I2; PGI2) is formed from arachidonic acid primarily by the vascular endothelium and renal cortex.{502,7044} It is a potent vasodilator and inhibitor of platelet aggregation.{7044} PGI2 is non-enzymatically hydrated to 6-keto PGF1α (t½ = 2-3 minutes), and then quickly converted to the major metabolite, 2,3-dinor-6-keto PGF1α (t½ = 30 minutes).{187,7403,440} Prostacyclin was once thought to be a circulating hormone that regulated platelet-vasculature interactions, but the rate of secretion into circulation coupled with the short half-life indicate that prostacyclin functions locally.{279} Although 6-keto PGF1α is commonly measured in plasma and urine as an estimate of prostacyclin synthesis, it should be noted that there may be more than one source of PGI2 in these samples. For instance, venipuncture may cause the release of prostacyclin which will artifactually increase the 6-keto PGF1α concentration in plasma.{6469} Urinary concentrations of 6-keto PGF1α are confounded by the fact that some plasma prostacyclin (~14%) is excreted into urine as 6-keto PGF1α and the remainder is of renal origin.{279,6469} Therefore, it is important to take these factors into account when analyzing data.
Prostacyclin (Prostaglandin I2; PGI2) is formed from arachidonic acid primarily by the vascular endothelium and renal cortex.{502,7044} It is a potent vasodilator and inhibitor of platelet aggregation.{7044} PGI2 is non-enzymatically hydrated to 6-keto PGF1α (t½ = 2-3 minutes), and then quickly converted to the major metabolite, 2,3-dinor-6-keto PGF1α (t½ = 30 minutes).{187,7403,440} Prostacyclin was once thought to be a circulating hormone that regulated platelet-vasculature interactions, but the rate of secretion into circulation coupled with the short half-life indicate that prostacyclin functions locally.{279} Although 6-keto PGF1α is commonly measured in plasma and urine as an estimate of prostacyclin synthesis, it should be noted that there may be more than one source of PGI2 in these samples. For instance, venipuncture may cause the release of prostacyclin which will artifactually increase the 6-keto PGF1α concentration in plasma.{6469} Urinary concentrations of 6-keto PGF1α are confounded by the fact that some plasma prostacyclin (~14%) is excreted into urine as 6-keto PGF1α and the remainder is of renal origin.{279,6469} Therefore, it is important to take these factors into account when analyzing data.
| Size | 96 solid wells |
| Shipping | dry ice |
| Custom Code | 3822.19 |
| UNSPSC code | 41116104 |
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