17-phenyl trinor Prostaglandin F_2? cyclopropyl methyl amide

Biochemicals - Lipids

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Cat No: 10010810

Biochemicals - Lipids

Prostaglandin F2α (PGF2α) activates the FP receptor, promoting smooth muscle contraction and luteolysis. 17-phenyl trinor PGF2α binds the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF2α.{2058} It is produced...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

9?,11?,15S-trihydroxy-17-phenyl-18,19,20-trinor-prosta-5Z,13E-dien-1-cyclopropyl methyl amide

Correlated keywords:

prostaglandins F2? PGF2? FP receptors luteolysis analogs bimatoprosts glaucoma intraocular pressure IOP PGs

Product Overview:
Prostaglandin F2α (PGF2α) activates the FP receptor, promoting smooth muscle contraction and luteolysis. 17-phenyl trinor PGF2α binds the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF2α.{2058} It is produced in vivo by the hydrolysis of 17-phenyl trinor PGF2α ethyl amide.{12894} 17-phenyl trinor PGF2α ethyl amide is used to reduce intraocular pressure related to glaucoma.{12188} 17-phenyl trinor PGF2α cyclopropyl methyl amide is a lipophilic analog of 17-phenyl trinor PGF2α. Amides of PGs may serve as prodrugs, as they are hydrolyzed in certain tissues to generate the bioactive free acid.

Size	1 mg
Shipping	dry ice
CAS Number	1138395-10-4
Molecular Formula	C₂₇H₃₉NO₄
SMILES	O[C@@H](CCC1=CC=CC=C1)/C=C/[C@H]2[C@H](O)C[C@H](O)[C@@H]2C/C=C\CCCC(NCC3CC3)=O
Molecular Weight	441,6
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2937.50
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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