SP 600125

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SP 600125

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Cat No: 10010466

Biochemicals - Kinase Inhibitors

SP 6000125 is a pan-inhibitor of JNK (IC50s = 0.04, 0.04, and 0.09 µM for JNK1, -2, and -3, respectively).{16589} It is greater than 300-fold selective for these enzymes over a panel of 17 additional kinases at 10 µM. SP 6000125 reduces LPS-induced pr...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

anthra[1,9-cd]pyrazol-6(2H)-one

Correlated keywords:

c-Jun cJun JNKs inhibitors inhibits inhibition reversible cell-permeable cells COX-2 COX2 MAP kinase MAPK genes expressions apoptosis autophagy differentiation IL-10 IL10 TNF-? TNF? IFN-? IFN? T-cells Tcells HeLa sp600125 ferroptosis JNK1 JNK2 JNK3 f IL1? IL8 antiCD3 antiCD28 CA 1

Product Overview:
SP 6000125 is a pan-inhibitor of JNK (IC50s = 0.04, 0.04, and 0.09 µM for JNK1, -2, and -3, respectively).{16589} It is greater than 300-fold selective for these enzymes over a panel of 17 additional kinases at 10 µM. SP 6000125 reduces LPS-induced production of IL-1β, IL-8, and TNF-α in isolated human peripheral blood monocytes, as well as decreases anti-CD3- and anti-CD28-induced production of IFN-γ, TNF-α, and IL-10 induced by in Th1-polarized Jurkat cells, in a concentration-dependent manner. It inhibits LPS-induced production of reactive oxygen species (ROS) in, and NETosis of, isolated human neutrophils when used at a concentration of 10 µM.{58723} Intracerebroventricular administration of SP 6000125 (30 µg/animal) prevents neuronal death in the CA1 region of the hippocampus in a rat model of transient global ischemia-reperfusion injury induced by four-vessel occlusion.{58724}

Size	5 mg
Shipping	dry ice
CAS Number	129-56-6
Molecular Formula	C₁₄H₈N₂O
SMILES	O=c1c2ccccc2c2n[nH]c3cccc1c23
Molecular Weight	220,2
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2922.19
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.