JNK Inhibitor XVI

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JNK Inhibitor XVI

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Cat No: 18096

Biochemicals - Kinase Inhibitors

c-Jun N-terminal kinases (JNKs) are MAP kinase family members that become highly activated after cells are exposed to stress conditions and are poorly activated by exposure to growth factors or mitogens. JNK inhibitor XVI is a selective, irreversible J...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3-[[4-(dimethylamino)-1-oxo-2-buten-1-yl]amino]-N-[3-methyl-4-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-benzamide

Correlated keywords:

1644498-56-5 JNK1 JNK2 JNK3 JNK-1 JNK-2 JNK-3 JNKIN8 c-Jun N-terminal kinase 8 cJun A-375 JNKIN-8 JNK-IN8

Product Overview:
c-Jun N-terminal kinases (JNKs) are MAP kinase family members that become highly activated after cells are exposed to stress conditions and are poorly activated by exposure to growth factors or mitogens. JNK inhibitor XVI is a selective, irreversible JNK inhibitor (IC50s = 4.67, 18.7, and 0.98 nM for JNK1, 2, and 3, respectively) that prevents phosphorylation of c-Jun in A375 and HeLa cells with EC50 values of 338 and 486 nM, respectively.{30801} It has been shown to inhibit JNK kinase activity by a mechanism that depends on covalent modification of cysteine116 in the ATP-binding motif.{30801} This compound has been used to explore the role of JNK in mediating cancer cell death.{30800,29518}

Size	1 mg
Shipping	dry ice
CAS Number	1410880-22-6
Molecular Formula	C₂₉H₂₉N₇O₂
SMILES	CN(C)C/C=C/C(NC1=CC=CC(C(NC2=CC=C(NC3=NC=CC(C4=CN=CC=C4)=N3)C(C)=C2)=O)=C1)=O
Molecular Weight	507,6
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2933.59
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.