JNK Inhibitor IX

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JNK Inhibitor IX

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Cat No: 15624

Biochemicals - Kinase Inhibitors

c-Jun N-terminal kinases (JNKs) are MAP kinase family members that become highly activated after cells are exposed to stress conditions and are poorly activated by exposure to growth factors or mitogens.{17156} They have been implicated in neurodegener...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thien-2-yl)-1-naphthalenecarboxamide

Correlated keywords:

JNKs JNK2 JNK3 inhibitors inhibits inhibitions kinases MAPK MAP stress activated selective JNK-2 JNK-3 2 3 two three c-jun amino terminals thienylnaphthamide ATPs binding sites arthritis cancers diabetes inflammation intracellular signaling signals neurosciences proteins transduction JNK2/3

Product Overview:
c-Jun N-terminal kinases (JNKs) are MAP kinase family members that become highly activated after cells are exposed to stress conditions and are poorly activated by exposure to growth factors or mitogens.{17156} They have been implicated in neurodegeneration, rheumatoid arthritis, inflammation, cancer, and diabetes. JNK1 and JNK2 are widely expressed throughout the body whereas JNK3 is predominantly distributed in the brain. JNK Inhibitor IX is a thienylnaphthamide compound that targets the ATP binding site of JNK2 and JNK3, disrupting activity with pIC50 values of 6.5 and 6.7, respectively.{25564} It demonstrates little activity against JNK1, p38α, and a panel of more than 30 other kinases (pIC50 < 5.0).{25564}

Size	5 mg
Shipping	room temp.
CAS Number	312917-14-9
Molecular Formula	C₂₀H₁₆N₂OS
SMILES	O=C(C1=CC=CC2=C1C=CC=C2)NC3=C(C#N)C4=C(S3)CCCC4
Molecular Weight	332,4
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2930.90
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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