?-Tocotrienol

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?-Tocotrienol

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Cat No: 10008513

Biochemicals - Natural Products

δ-Tocotrienol is a form of vitamin E that has been found in rice bran and has diverse biological activities.{3679,14290,14291,58093} It reduces cell death induced by hydrogen peroxide, paraquat, S-nitrocysteine, SIN-1 (Item No. 82220), or L-buthionine...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3,4-dihydro-2,8-dimethyl-2R-[(3E,7E)-4,8,12-trimethyl-3,7,11-tridecatrienyl]-2H-1-benzopyran-6-ol

Correlated keywords:

d-Tocotrienol delta-Tocotrienol a-Tocotrienol alpha-Tocotrienol .alpha.-Tocotrienol vitamin E tocopherols tocotrienols antioxidants apoptosis palm oils rice brans neurons neuroprotectors neuroprotection H2O2 hydrogen peroxides cells death Snitrocysteines SIN1 cytotoxicity inhibits inhibitors inhibition HAECs U937 monocytic cells VCAM1 TNF? IL6 IL1? IFN?

Product Overview:
δ-Tocotrienol is a form of vitamin E that has been found in rice bran and has diverse biological activities.{3679,14290,14291,58093} It reduces cell death induced by hydrogen peroxide, paraquat, S-nitrocysteine, SIN-1 (Item No. 82220), or L-buthionine-(S,R)-sulfoximine (BSO; Item No. 14484) in rat striatal cultures when used at concentrations ranging from 0.1 to 10 µM.{14290} δ-Tocotrienol (10 µM) reduces 25-hydroxycholesterol-induced surface expression of VCAM-1 in human aortic endothelial cells (HAECs), as well as reduces 25-hydroxycholesterol-induced HAEC adhesion to U937 monocytes.{14291} It inhibits LPS-induced production of nitric oxide (NO), TNF-α, IL-6, IL-1β, and IFN-γ in RAW 264.7 cells. δ-Tocotrienol (60 mg/kg) increases the glomerular filtration rate and decreases renal malondialdehyde (MDA) levels in a rat model of nephrotoxicity induced by ochratoxin A (Item No. 11439).{58094} [Matreya, LLC. Catalog No. 2112]

Size	1 mg
Shipping	dry ice
CAS Number	25612-59-3
Molecular Formula	C₂₇H₄₀O₂
SMILES	C/C(CC/C=C(C)/CC/C=C(C)/C)=C\CC[C@@]1(C)OC2=C(C)C=C(O)C=C2CC1
Molecular Weight	396,6
Formulation	A solution in ethanol
Purity	≥98%
Custom Code	2932.99
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.