HX 1171

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HX 1171

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Cat No: 22652

Biochemicals - Ox Stress Reagents

HX 1171 is a derivative of vitamin E that has lipid peroxidative, antioxidant, and cancer-related activities.{37281,37279,37282} It inhibits lipid peroxidation by 98 and 40% when used at concentrations of 10 and 1 µM, respectively, in rat liver micros...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4-(hexyloxy)-2,3,6-trimethyl-phenol

Correlated keywords:

hexyl-trimethylhydroquinone anti-oxidant A-549 HX1171 NRF-2 NQO HMOX 1

Product Overview:
HX 1171 is a derivative of vitamin E that has lipid peroxidative, antioxidant, and cancer-related activities.{37281,37279,37282} It inhibits lipid peroxidation by 98 and 40% when used at concentrations of 10 and 1 µM, respectively, in rat liver microsomes.{37281} It activates NRF2 by enhancing its nuclear translocation and transcriptional activity, increasing the expression of the antioxidant-related enzymes NQO1 and HMOX1 in A549 human lung epithelial cells.{37280} HX 1171 (30 mg/kg) reduces the amount of fibrosis and the level of fibrotic markers in liver and primary hepatocytes, respectively, from rats with carbon tetrachloride-induced liver cirrhosis.{37279} It also decreases the incidence of hepatocellular adenomas and hemangiosarcomas in rats treated with the aminopyrine (AP) and sodium nitrite (NaNO2), but increases the incidence of forestomach carcinoma when administered with AP and NaNO2 or NaNO2 alone.{37282}

Size	50 mg
Shipping	dry ice
CAS Number	148081-72-5
Molecular Formula	C₁₅H₂₄O₂
SMILES	OC1=C(C)C(C)=C(OCCCCCC)C=C1C
Molecular Weight	236,4
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2907.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.