?-Tocotrienol

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?-Tocotrienol

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Cat No: 10008377

Biochemicals - Natural Products

α-Tocotrienol is an antioxidant and a form of vitamin E that has been found in rice bran and has neuroprotective properties.{3679,14290,14292,52764} It reduces cell death induced by hydrogen peroxide, paraquat, S-nitrocysteine, SIN-1 (Item No. 82220),...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3,4-dihydro-2,5,7,8-tetramethyl-2R-[(3E,7E)-4,8,12-trimethyl-3,7,11-tridecatrienyl)]-2H-1-benzopyran-6-ol

Correlated keywords:

vitamin E tocopherols tocotrienols antioxidants neuroprotectors H2O2 S-nitrocysteines SIN1 HT-4 cytosolic glutamatec-Src kinases 12-lipoxygenases 12-LOs BclxL ?NBclxL ?NBcl-xL 1721-51-3

Product Overview:
α-Tocotrienol is an antioxidant and a form of vitamin E that has been found in rice bran and has neuroprotective properties.{3679,14290,14292,52764} It reduces cell death induced by hydrogen peroxide, paraquat, S-nitrocysteine, SIN-1 (Item No. 82220), or L-buthionine-(S,R)-sulfoximine (BSO; Item No. 14484) in rat striatal cultures when used at concentrations ranging from 0.1 to 10 µM.{14290} Cytosolic microinjection of α-tocotrienol prevents glutamate-induced cell death and phosphorylation of 12-lipoxygenase (12-LO) in HT4 neurons.{14292} It reduces glutamate-induced cytosolic and mitochondrial production of reactive oxygen species (ROS), accumulation of N-terminally truncated Bcl-xL (ΔN-Bcl-xL), and cell death in primary rat hippocampal neurons.{52764} α-Tocotrienol (50 mg/kg) reduces infarct size in a spontaneously hypertensive rat model of stroke induced by tandem right common carotid artery and middle cerebral artery occlusion.{14292} [Matreya, LLC. Catalog No. 2109]

Size	1 mg
Shipping	dry ice
CAS Number	58864-81-6
Molecular Formula	C₂₉H₄₄O₂
SMILES	C[C@]1(CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/C)OC2=C(C)C(C)=C(O)C(C)=C2CC1
Molecular Weight	424,7
Formulation	A solution in ethanol
Purity	≥98%
Custom Code	2932.99
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.