(?)-Epigallocatechin Gallate

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Cat No: 70935

(–)-Epigallocatechin gallate (EGCG) is a phenol that has been found in green and black tea plants and has diverse biological activities.{41816,3193,7634,15553,25719,15552,55280} It is lytic against T. cruzi amastigotes, with a 50% bactericidal concent...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3,4-dihydro-5,7-dihydroxy-2R-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3R-yl-3,4,5-trihydroxy-benzoate

Correlated keywords:

863-65-0 phenolic flavonoids antioxidants lipoproteins oxidative injury stress plants green black teas oxidation nitric oxide epicatechin

Product Overview:
(–)-Epigallocatechin gallate (EGCG) is a phenol that has been found in green and black tea plants and has diverse biological activities.{41816,3193,7634,15553,25719,15552,55280} It is lytic against T. cruzi amastigotes, with a 50% bactericidal concentration (MBC50) value of 0.53 pM.{41816} EGCG decreases deoxyguanosine oxidation and tyrosine nitration (IC50s = 0.25 and 0.11 mM, respectively) and inhibits macrophage-mediated LDL oxidation in vitro.{3193,7634} EGCG increases LDL receptor binding activity and lowers cholesterol levels in HepG2 cells via increased cholesterol efflux.{15553} It inhibits heregulin-β1-induced activation of ErbB2 and ErbB3, as well as migration and invasion of MCF-7 breast cancer cells.{25719} In vivo, EGCG reduces food intake and body weight, serum levels of insulin, leptin, testosterone, and growth hormone, and the size of the ventral prostate, testis, liver, and spleen in male Sprague Dawley, lean Zucker, and obese Zucker rats when administered at doses of 82, 81, and 92 mg/kg, respectively.{15552} It also reduces increases in hepatic steatosis, inflammatory cell infiltration, and injury in a mouse model of non-alcoholic steatohepatitis (NASH) induced by a methionine- and choline-deficient diet when administered at doses of 50 and 100 mg/kg.{55280}

Size	50 mg
Shipping	dry ice
CAS Number	989-51-5
Molecular Formula	C₂₂H₁₈O₁₁
SMILES	Oc1cc(O)c2C[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@H](Oc2c1)c1cc(O)c(O)c(O)c1
Molecular Weight	458,4
Formulation	A crystalline solid
Purity	≥96%
Custom Code	2907.29
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.