Tiopronin

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Tiopronin

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Cat No: 23720

Biochemicals - Ox Stress Reagents

Tiopronin is an antioxidant that has diverse biological activities.{37228,37229,37230,37231,37232} It reduces free radical production by murine macrophages and granulocytes in vitro in a dose-dependent manner.{37228} Tiopronin induces expression of hy...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-(2-mercapto-1-oxopropyl)-glycine

Correlated keywords:

33068-82-5 BRN1859822 Acadione Capen Captimer Epatiol Hepadigest MPG Meprin detoxicant Mercaptopropionylglycine Mucolysin N-(2-Mercaptopropionyl)glycine NMNG Sutilan Cusi Thiola Thiolpropionamidoacetic acid Thiopronin Thiopronine Thiosol Tioglis tiopronine Tiopronino Tioproninum Vincol CCRIS 1935 CCRIS1935 DL-(?-Mercaptopropionyl)glycine MNG anti-oxidant HIF1a HIF1? vascular endothelial growth factor MPO proinflammatory nonalcoholic

Product Overview:
Tiopronin is an antioxidant that has diverse biological activities.{37228,37229,37230,37231,37232} It reduces free radical production by murine macrophages and granulocytes in vitro in a dose-dependent manner.{37228} Tiopronin induces expression of hypoxia-inducible factor 1α (HIF-1α) and increases VEGF secretion in human colon carcinoma cells.{37229} Rectal administration (500 μL of a 10 mM solution) reduces myeloperoxidase activity and reduces pro-inflammatory cytokine production in the colon in a rat model of colitis. Tiopronin (80-320 mg/kg per day) reduces the incidence of cleft palate in fetuses born to female mice orally exposed to teratogenic methylmercury chloride.{37230} Tiopronin (100 mg/kg) reduces heme oxygenase 1 mRNA expression, lipid peroxidation, and transverse aortic constriction in a mouse model of cardiac hypertrophy.{37231} Tiopronin (20 mg/kg) is hepatoprotective, increasing activity of the antioxidant enzymes superoxide dismutase and glutathione peroxidase and reversing hepatocyte degeneration in a rat model of high-fat diet-induced non-alcoholic steatohepatitis.{37232}

Size	1 g
Shipping	dry ice
CAS Number	02/02/1953 00:00
Molecular Formula	C₅H₉NO₃S
SMILES	OC(CNC(C(S)C)=O)=O
Molecular Weight	163,2
Formulation	A solid
Purity	≥98%
Custom Code	2924.19
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.