?4-Abiraterone

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?⁴-Abiraterone

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Cat No: 27594

Biochemicals - Lipids

Δ4-Abiraterone (D4A) is an active metabolite of the CYP17A1 inhibitor abiraterone (Item No. 9002768).{47328} D4A is an androgen receptor antagonist (IC50 = 5.3 nM) that reduces expression of the androgen receptor target genes PSA, TMPRSS2, and FKBP5 i...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

17-(3-pyridinyl)-androsta-4,16-dien-3-one

Correlated keywords:

CB7627 ? 4 D4 CYP 17 A1 CYP17 17A1 TMPR SS2 TMP RSS2 FKB P5 FKBP 5 LNC aP LAPC 4 C42 P 450 SRD 5A LAP C4 VC

Product Overview:
Δ4-Abiraterone (D4A) is an active metabolite of the CYP17A1 inhibitor abiraterone (Item No. 9002768).{47328} D4A is an androgen receptor antagonist (IC50 = 5.3 nM) that reduces expression of the androgen receptor target genes PSA, TMPRSS2, and FKBP5 in LNCaP, LAPC4, and C4-2 cell lines. It inhibits the cytochrome P450 (CYP) isoform CYP17A1 by 66.5% when used at a concentration of 1 nM. D4A (10 μM) also blocks SRD5A conversion of Δ4-androstenedione to 5α-androstanedione in LAPC4 cells. In vivo, D4A delays tumor progression in a VCaP mouse xenograft model and increases progression-free survival in a C4-2 mouse xenograft model.

Size	1 mg
Shipping	dry ice
CAS Number	154229-21-7
Molecular Formula	C₂₄H₂₉NO
SMILES	O=C1CC[C@@]2(C)C(CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC=C4C5=CN=CC=C5)=C1
Molecular Weight	347,5
Formulation	A solid
Purity	≥98%
Custom Code	2937.29
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.