Abiraterone

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Abiraterone

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Cat No: 9002768

Biochemicals - Lipids

Abiraterone is the active metabolite of abiraterone acetate (Item No. 15148). Abiraterone blocks cytochrome P450 17A1 (also known as steroid 17α-hydroxylase/17,20 lyase) by potently inhibiting both the 17α-hydroxylase and the 17,20 lyase activities (I...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(3?)-17-(3-pyridinyl)-androsta-5,16-dien-3-ol

Correlated keywords:

CB7598 Zytiga cytochrome P450 17A1 CYP45017A1 steroid 17?-hydroxylase/17,20 lyase 17?-hydroxylase 17,20 lyase CYP17A1 antiandrogen antineoplastic anti-androgen anti-neoplastic prostate chemotherapy P45017?1 17?1

Product Overview:
Abiraterone is the active metabolite of abiraterone acetate (Item No. 15148). Abiraterone blocks cytochrome P450 17A1 (also known as steroid 17α-hydroxylase/17,20 lyase) by potently inhibiting both the 17α-hydroxylase and the 17,20 lyase activities (IC50 = 18 and 17 nM, respectively).{24421,24420} In mice as well as men, it essentially eliminates plasma testosterone while producing a 3- to 4-fold increase in plasma luteinizing hormone.{24421,24419} In clinical trials, abiraterone improves radiographic progression-free survival and significantly delays decline in human metastatic castration-resistant prostate cancer.{24418}

Size	1 mg
Shipping	dry ice
CAS Number	154229-19-3
Molecular Formula	C₂₄H₃₁NO
SMILES	O[C@H](C1)CC[C@@]2(C)C1=CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC=C4C5=CN=CC=C5
Molecular Weight	349,5
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2933.49
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.