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Abiraterone Acetate-d4

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    Abiraterone Acetate-d<sub>4</sub>
  • Abiraterone Acetate-d<sub>4</sub>
Cat No: 22096
Biochemicals - Isotopically Labeled Standards
Cayman

Abiraterone acetate-d4 is intended for use as an internal standard for the quantification of abiraterone acetate (Item No. 15148) by GC- or LC-MS. Abiraterone acetate is an inhibitor of the cytochrome P450 (CYP) isoform CYP17A1 (IC50s = 17 and 18 nM f...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • (3?)-17-(3-pyridinyl-2,4,5,6-d4)-androsta-5,16-dien-3-ol, 3-acetate
Correlated keywords:
  • deuterated deuterium GCMS LCMS CYP 450 17A1 CB7630 Zytiga VeroE6 E 6
Product Overview:
Abiraterone acetate-d4 is intended for use as an internal standard for the quantification of abiraterone acetate (Item No. 15148) by GC- or LC-MS. Abiraterone acetate is an inhibitor of the cytochrome P450 (CYP) isoform CYP17A1 (IC50s = 17 and 18 nM for inhibition of C17,20-lyase and 17α-hydroxylase activities, respectively).{24420} It is also a prodrug form of abiraterone (Item No. 9002768).{24421} Abiraterone acetate reduces plasma testosterone levels, increases plasma luteinizing hormone levels, and reduces ventral prostate, seminal vesicle, testis, and kidney weight in mice when administered at doses of 0.1 and 0.5 mmol/kg per day. It also reduces severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load in the culture supernatant of infected Vero E6 cells (EC90 = 8.4 μM) and is active in a plaque reduction assay (EC50 = 1.94 μM).{59330} Formulations containing abiraterone acetate have been used in combination therapy for the treatment of metastatic castration-resistant prostate cancer.
Size 500 µg
Shipping wet ice
CAS Number 2122245-63-8
Molecular Formula C26H29D4NO2
SMILES C[C@]12C(C[C@@H](OC(C)=O)CC2)=CC[C@]3([H])[C@]1([H])CC[C@@]4(C)[C@@]3([H])CC=C4C5=C([2H])N=C([2H])C([2H])=C5[2H]
Molecular Weight 395,6
Formulation A solid
Purity ≥99% deuterated forms (d1-d4)
Custom Code 3822.19
UNSPSC code 12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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