?-Eudesmol

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?-Eudesmol

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Cat No: 25771

Biochemicals - Ion Channel Modulation

β-Eudesmol is a sesquiterpene that has been found in a variety of plants, including Cannabis, and has diverse biological activities.{42303,36865} It is a noncompetitive antagonist of nicotinic acetylcholine receptors (nAChRs) that decreases the open t...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(2R,4aR,8aS)-decahydro-?,?,4a-trimethyl-8-methylene-2-naphthalenemethanol

Correlated keywords:

Selinenol CB non-competitive SGC7901 BEL7402 H-22 S180 TRPA TRPV-3 TRPM-8

Product Overview:
β-Eudesmol is a sesquiterpene that has been found in a variety of plants, including Cannabis, and has diverse biological activities.{42303,36865} It is a noncompetitive antagonist of nicotinic acetylcholine receptors (nAChRs) that decreases the open time and opening frequency of nAChR channels when used at concentrations of 40 and 80 µM and increases the decay phase of depolarization when used at a concentration of 100 µM in isolated mouse diaphragm muscle.{36866} β-Eudesmol (50-100 µM) inhibits VEGF- and bFGF-induced proliferation in human umbilical vein endothelial cells (HUVECs).{36867} It also inhibits proliferation of HeLa, SGC-7901, and BEL-7402 cells when used at concentrations ranging from 10 to 100 µM and reduces tumor growth in H22 and S-180 mouse tumor models when administered at doses ranging from 2.5 to 5 mg/kg. β-Eudesmol is an agonist of the transient receptor potential (TRP) receptor subtypes TRPA1, TRPV3, and TRPM8 and increases food intake and plasma levels of ghrelin in rats.{36868,36869}

Size	500 µg
Shipping	dry ice
CAS Number	473-15-4
Molecular Formula	C₁₅H₂₆O
SMILES	C=C1[C@@]2([H])[C@](CC[C@@H](C(O)(C)C)C2)(C)CCC1
Molecular Weight	222,4
Formulation	A solid
Purity	≥95%
Custom Code	2902.90
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.