?-Humulene

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?-Humulene

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Cat No: 21574

Biochemicals - Natural Products

α-Humulene is a sesquiterpene that has been found in C. sativa, C. indica, and hemp with diverse biological activities.{41453,39866,39867,39868,39869} It is lethal to A. subpictus, A. albopictus, and C. tritaeniorhynchus mosquito larvae (LC50s = 6.19,...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2,6,6,9-tetramethyl-1E,4E,8E-cycloundecatriene

Correlated keywords:

19132-75-3 65907-25-7 cannabis monocyclic antiinflammatory anti-inflammatory Cannabis Anopheles Aedes Culex Caco2 MCF7 TNF? IL1? COX2 E-2 PGE-2

Product Overview:
α-Humulene is a sesquiterpene that has been found in C. sativa, C. indica, and hemp with diverse biological activities.{41453,39866,39867,39868,39869} It is lethal to A. subpictus, A. albopictus, and C. tritaeniorhynchus mosquito larvae (LC50s = 6.19, 7.39, and 12.05 mg/ml, respectively).{39866} α-Humulene reduces growth of MCF-7 breast cancer cells by approximately 50% when used at a concentration of 32 mg/ml.{39867} It also reduces viability of Caco-2 cells in a concentration-dependent manner (IC50 = 24.4 mg/ml) but has no effect on viability of rat hepatocytes.{39868} In vivo, α-humulene (50 mg/kg) reduces histamine-induced paw edema in mice as well as carrageenan-induced TNF-α and IL-1β production and paw edema in mice and rats.{39869} It also reduces carrageenan-induced production of prostaglandin E2 (PGE2) and expression of inducible nitric oxide synthase (iNOS) and COX-2 in rats.

Size	100 mg
Shipping	dry ice
CAS Number	6753-98-6
Molecular Formula	C₁₅H₂₄
SMILES	C/C1=C\CC/C(C)=C/CC(C)(C)/C=C/C1
Molecular Weight	204,4
Formulation	A neat oil
Purity	≥97%
Custom Code	2902.90
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.