Bombesin (trifluoroacetate salt)

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Cat No: 24151

Biochemicals - Peptides

Bombesin is a neuropeptide with diverse biological activities originally isolated from the skin of B. bombina and B. variegata variegata amphibians.{40598,40599} It binds to the gastrin-releasing peptide receptor (GRPR) in rat pancreatic acinar cells...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

5-oxo-L-prolyl-L-glutaminyl-L-arginyl-L-leucylglycyl-L-asparaginyl-L-glutaminyl-L-tryptophyl-L-alanyl-L-valylglycyl-L-histidyl-L-leucyl-L-methioninamide, trifluoroacetate salt

Correlated keywords:

chinese-hamster-ovary tetradecapeptide bauhinia fire-belly toad 31362-50-2

Product Overview:
Bombesin is a neuropeptide with diverse biological activities originally isolated from the skin of B. bombina and B. variegata variegata amphibians.{40598,40599} It binds to the gastrin-releasing peptide receptor (GRPR) in rat pancreatic acinar cells (Ki = 1.88 nM) and to frog bombesin receptor subtype 4 (BB4) in CHO cells overexpressing the receptor (Ki = 1.7 nM).{40600} Hypothalamic paraventricular microinfusion of bombesin (100 ng per animal) increases blood glucose, free fatty acids, and corticosterone levels in rats.{40601} Bombesin (50 ng per animal) injection into the preoptic area decreases food intake by food-deprived or insulin pretreated rats.{40602} It delays gastric emptying in rats by 55.8% when administered at a dose of 16 μg/kg (i.p.) and inhibits gastric secretion at a dose of 500 ng per animal.{40603,40604}

Size	500 µg
Shipping	dry ice
Molecular Formula	C₇₁H₁₁₀N₂₄O₁₈S • XCF₃COOH
SMILES	O=C(N[C@H](C(N[C@@H](C(C)C)C(NCC(N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)CCSC)=O)=O)CC1=CN=CN1)=O)=O)=O)C)[C@@H](NC([C@H](CCC(N)=O)NC([C@H](CC(N)=O)NC(CNC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@H]2CCC(N2)=O)=O)CCC(N)=O)=O)=O)CC(C)C)=O)=O)=O)=O)CC3=CN
Molecular Weight	1619,9
Formulation	A lyophilized powder
Purity	≥95%
Custom Code	3504.00
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.