Neurotensin (trifluoroacetate sa

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Neurotensin (trifluoroacetate salt)

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Cat No: 24717

Biochemicals - Peptides

Neurotensin is a neuropeptide that is distributed throughout the CNS and in enteroendocrine cells of the small intestine that has diverse biological activities.{36494,36495,36496,36497} In vivo, neurotensin (10-50 μg per hour, i.c.v.) induces hypother...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

central nervouse system IL8 FA 39379-15-2

Product Overview:
Neurotensin is a neuropeptide that is distributed throughout the CNS and in enteroendocrine cells of the small intestine that has diverse biological activities.{36494,36495,36496,36497} In vivo, neurotensin (10-50 μg per hour, i.c.v.) induces hypothermia in rats.{36495} Neurotensin signaling is increased and induces analgesia in wild-type mice, and neurotensin knockout mice are defective in basal nociceptive and stress-induced analgesic responses in a cold water swim stress test.{36496} It acts as an indirect dopamine antagonist that inhibits dopamine-induced effects at pre- and postsynaptic dopamine receptors.{36497} Neurotensin inhibits small bowel motility and secretion of gastric acid, stimulates pancreatic and biliary secretion, increases fatty acid absorption, and stimulates growth of the stomach, colon, pancreas, and small bowel in rats.{36494} It also increases growth of breast, pancreatic, and hepatocellular carcinoma cells via induction of IL-8 secretion and activation of epithelial mesenchymal transition (EMT) in vitro and in vivo.

Size	1 mg
Shipping	dry ice
Molecular Formula	C₇₈H₁₂₁N₂₁O₂₀ • XCF₃COOH
SMILES	CC(C[C@H](NC([C@H]1NC(CC1)=O)=O)C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCCN)C(N2CCC[C@H]2C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N3CCC[C@H]3C(N[C@H](C(N[C@](C(N[C@@H](CC(C)C)C(O)=O)=O)([C@H](CC)C)[H])=O)CC4=CC=C(O)C=C4)=O)=O)=O)=O)=O
Molecular Weight	1672,9
Formulation	A lyophilized powder
Purity	≥95%
Custom Code	3504.00
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.