ICI 216140

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ICI 216140

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Cat No: 17479

Biochemicals - Receptor Pharmacology

Bombesin is a peptide, originally isolated from the skin of the European fire-bellied toad, with pressor and sympathoexcitatory activity. Its three receptors are distributed throughout the central and peripheral nervous system and are involved in gastr...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-(2-methyl-1-oxopropyl)-7-D-alanine-9-(N-methyl-L-leucinamide)-3-9-neuromedin C

Correlated keywords:

gastrin-releasing peptide GRP bombesin receptor 2 antagonist hypertension biochemical metabolism ICI216140 ICI216,140 ICI 216,140 L-Leucinamide (CH3)2CHCO-His-Trp-Ala-Val-D-Ala-His-Leu-NHCH3

Product Overview:
Bombesin is a peptide, originally isolated from the skin of the European fire-bellied toad, with pressor and sympathoexcitatory activity. Its three receptors are distributed throughout the central and peripheral nervous system and are involved in gastric acid secretion, emotional response, temperature control, learning, and memory. Neuromedin B and gastrin-releasing peptide (GRP) are mammalian homologs of bombesin.{28635} ICI 216140 is a GRP/bombesin receptor 2 antagonist (IC50 = 2 nM in vitro).{28634} At 2 mg/kg, it can reduce bombesin-stimulated pancreatic amylase secretion in rats.{28634} At 1 mM, it has been shown to attenuate bombesin-stimulated increases in blood pressure in rats.{28636}

Size	500 µg
Shipping	dry ice
CAS Number	124001-41-8
Molecular Formula	C₄₅H₆₅N₁₃O₈
SMILES	CC(C)C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CC2=CNC3=C2C=CC=C3)C(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@H](C)C(N[C@@H](CC4=CNC=N4)C(N[C@@H](CC(C)C)C(NC)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Weight	916,1
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2922.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.