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Ohtsuki S., Uchida Y., Kubo Y., Terasaki T., Quantitative targeted absolute proteomics-based ADME research as a new path to drug discovery and development: Methodology, advantages, strategy, and prospects, J. Pharm. Sci., 100: 3547–3559 (2011).
Kamiie J., Ohtsuki S., Iwase R., Ohmine K., Katsukura Y., Yanai K., Sekine Y., Uchida Y., Ito S., Terasaki T., Quantitative atlas of membrane transporter proteins: development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria. Pharm. Res., 25: 1469-1483 (2008).
Sakamoto A., Matsumaru T., Ishiguro N., Schaefer O., Ohtsuki S., Inoue T., Kawakami H., Terasaki T., Reliability and robustness of simultaneous absolute quantification of drug transporters, cytochrome P450 enzymes, and Udp-Glucuronosyltranferases in human liver tissue by multiplexed MRM/selected reaction monitoring mode tandem mass spectrometer with nano-liquid chromatography, J. Pharm. Sci., 100: 4037–4043 (2011).
Kawakami H., Ohtsuki S., Kamiie J., Suzuki T., Abe T., Terasaki T., Simultaneous Absolute Quantifi cation of 11 Cytochrome P450 Isoforms in Human Liver Microsomes by Liquid Chromatography Tandem Mass Spectrometry with In Silico Target Peptide Selection, J. Pharm. Sci., 100: 341–352 (2011).
Ohtsuki S., Schaefer O., Kawakami H., Inoue T., Liehner S., Sato A., Ishiguro N., Kishimoto W., Ludwig-Schwellinger E., Ebner T., and Terasaki T., Simultaneous absolute protein quantifi cation of transporters, Cytochrome P450s and UDP glucuronosyltransferases as a
novel approach for the characterization of individual human liver: Comparison with mRNA levels and activities. Drug Metab. Dispos., 40(1):83-92 (2012)
Shawahna R., Uchida Y., Decleves X., Ohtsuki S., Yousif S., Dauchy S., Jacob A., Chassoux F., Daumas C., Couraud PO., Terasaki T., Scherrmann JM., Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels. Mol. Pharm., 8: 1332-1341 (2011).
Uchida Y., Ohtsuki S., Kamiie J., Terasaki T., Blood-Brain Barrier (BBB) Pharmacoproteomics (PPx): Reconstruction of In Vivo Brain Distribution of 11 Pglycoprotein Substrates based on the BBB Transporter Protein Concentration, In Vitro Intrinsic Transport Activity, and Unbound Fraction in Plasma and Brain in Mice J. Pharmacol. Exp. Ther., 339: 579-588 (2011).
MS2Plex® is a brand name of Bertin Bioreagent.
MS2Plex® comes from an original technology, developed by Professor Tetsuya Terasaki from Tohoku University, Sendai, Japan. MS2Plex® is a significant breakthrough in membrane protein analysis. This Quantitative Targeted Absolute Proteomics (QTAP) is based on the identification and separation of protein digests by liquid chromatography linked tandem mass spectrometry with multiple reaction monitoring. Bertin Bioreagent has signed a worldwide exclusive license for this patented technology.
To better serve you, we aim to design our products and reagents to address your needs on the expected performance in terms of a possible range of use, but also on operational conditions of use & regulations. Thanks to our production processes and quality controls, we provide you with products with compliance to specifications.
Our technical support & science teams are available to help you assess their relevance depending on your needs, to specify the conditions of application and their fields of use. Finally, our researchers are ready to provide you with the necessary support by going, if needed, in your laboratories to validate your operating conditions and to solve possible problems.