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Anthrax Edema Factor Assay kit

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    Anthrax Edema Factor Assay kit
  • Anthrax Edema Factor Assay kit
Cat No: A05230
Price is excluding VAT and does not include packaging neither shipping

Anthrax is an infectious disease due to Bacillus anthracis, a gram-positive, spore-forming bacterium. Among bioterrorist agents, anthrax is considered as one of the most potent and dangerous bio-agent and has been classifi ed in the A list of the Cente...

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: 96 wells

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Territorial Availability: Available worldwide directly through Bertin or your local distributor
Technical Warning: Check the Additional Items Required section of this kit booklet to verify if UltraPure Water (Milli-Q or equivalent) is needed for this assay
Product Overview:
Anthrax is an infectious disease due to Bacillus anthracis, a gram-positive, spore-forming bacterium. Among bioterrorist agents, anthrax is considered as one of the most potent and dangerous bio-agent and has been classifi ed in the A list of the Centers of Disease Control. The pathogenic power of this bacteria is due to an exotoxin, which is secreted into the host’s system when three nontoxic proteins link together to form a toxin complex. The three parts of the pathogen complex are protective antigen (PA), lethal factor (LF) and edema factor (EF).At molecular level, the PA binds to cell receptors where it is cleaved into PA20 and PA63. PA63 can competitively bind EF or LF or both. The PA-LF complex forms the lethal toxin (LTx) and the PA-EF complex forms the edema toxin (ETx). Once ETx is endocytosed, EF is released in cytosole. EF is a calmoduline and Ca2+ dependent adenylyl cyclase which catalyses the conversion of cytosolic adenosine triphosphate into cyclic adenosine monophosphate (cAMP) leading to edema.
Size: 96 wells
Shipping: dry ice
Stability: Store at -20degrees; shelf life 1 year maximum after production
Application Media: Human an mouse serum|No extraction required
Sample volume: 5 µL
Tracer: AcetylCholinesterase AChE
Detection Limit: 0.647 pg/mL
Standard Curve Range: 1 000 pg/mL - 7.81 pg/mL
Custom Code: 3822000000
UNSPSC code: 41116104

Grassi J, Pradelles P. Compounds labelled by the acetylcholinesterase of Electrophorus Electricus. Its preparation process and its use as a tracer or marquer in enzymo-immunological determinations. United States patent, N° 1,047,330. September 10, 1991

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