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KCNQ4 Potassium Channel Monoclonal Antibody (Clone S43-6)

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Cat No: 13713
Polyclonal&monoclonal Antibody - Miscellaneous Antibodies
Cayman
€368.00
Price is excluding VAT and does not include packaging neither shipping

Antigen: fusion protein amino acids 2-77 of human KCNQ4 • Host: mouse, clone S43-6 • Isotype: IgG1 • Cross Reactivity: (+) human, mouse, and rat KCNQ4 • Application(s): ICC, IP, and WB • The protein encoded by this gene forms a potassium channel tha...

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: 100 µg

This product can only be bought through Cayman Chemical. Please contact us.

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Territorial Availability: Available through Bertin Technologies only in Europe
Synonyms:
Product Overview:
Antigen: fusion protein amino acids 2-77 of human KCNQ4 • Host: mouse, clone S43-6 • Isotype: IgG1 • Cross Reactivity: (+) human, mouse, and rat KCNQ4 • Application(s): ICC, IP, and WB • The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and is activated by retigabine, a novel anti-convulsant drug.
Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells and their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage-gated ion channels, ligand-gated, other gating systems, and finally those that are classified differently, having more exotic characteristics. The first are voltage-gated ion channels which open and close in response to membrane potential. These are then seperated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels, each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels, and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels and transient receptor potential channels. The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and is activated by retigabine, a novel anti-convulsant drug.
Size: 100 µg
Shipping: wet ice
Stability: Store at -20 degrees; shelf life 365 days maximum after production
Host: Mouse
Antigen: fusion protein amino acids 2-77 of human KCNQ
Clone: S43-6
Isotype: IgG1
Application(s):

ICC, IP, and WB

Formulation: 100 µg of protein G-purified IgG in 100 µl PBS, pH 7.4, containing 50% glycerol and 0.09% sodium azide
Custom Code: 3822000002
UNSPSC code: 12352203

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

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