Confirm delete?

Bertin Bioreagent
logo

Search

Contact Us

TAF1 bromodomains 1 and 2 TR-FRET Assay Kit

  • Zoom
    TAF1 bromodomains 1 and 2 TR-<wbr/>FRET Assay Kit
  • TAF1 bromodomains 1 and 2 TR-<wbr/>FRET Assay Kit
Cat No: 600930
Assays - Miscellaneous
Cayman
€609.00
Price is excluding VAT and does not include packaging neither shipping

TAF1, a component of transcription factor IID, interacts with transcriptional activators to promote transcription. Recognition of acetylated lysine residues via its two bromodomains directs TAF1 binding to the core promoter sequences at the transcripti...

More

This product can only be bought through Cayman Chemical. Please contact us.

- +
Territorial Availability: Available through Bertin Technologies only in Europe
Technical Warning: Check the Additional Items Required section of this kit booklet to verify if UltraPure Water (Milli-Q or equivalent) is needed for this assay
Product Overview:
TAF1, a component of transcription factor IID, interacts with transcriptional activators to promote transcription. Recognition of acetylated lysine residues via its two bromodomains directs TAF1 binding to the core promoter sequences at the transcription start site. Through its interactions with the androgen receptor, TAF1 has been implicated in castration-resistant prostate cancer. TAF1 also has been shown to regulate expression of the pro-apoptotic protein p27kip1, potentially linking TAF1 expression to the cellular response to genotoxic stress. Cayman’s TAF1 bromodomains 1 and 2 TR-FRET Assay Kit is a homogeneous TR-FRET assay method amenable to rapid characterization of inhibitors of bromodomain/acetylated peptide interaction in a high throughput format. This screening assay kit is robust, displaying a Z' >0.6.
TAF1, a component of transcription factor IID, interacts with transcriptional activators to promote transcription. Recognition of acetylated lysine residues via its two bromodomains directs TAF1 binding to the core promoter sequences at the transcription start site. Through its interactions with the androgen receptor, TAF1 has been implicated in castration-resistant prostate cancer. TAF1 also has been shown to regulate expression of the pro-apoptotic protein p27kip1, potentially linking TAF1 expression to the cellular response to genotoxic stress. Cayman’s TAF1 bromodomains 1 and 2 TR-FRET Assay Kit is a homogeneous TR-FRET assay method amenable to rapid characterization of inhibitors of bromodomain/acetylated peptide interaction in a high throughput format. This screening assay kit is robust, displaying a Z' >0.6.
Size: 384 wells
Shipping: dry ice
Stability: Store at -80 degrees; shelf life 180 days maximum after production
Custom Code: 3822000002
UNSPSC code: 41116104

Kimura, J., Nguyen, S.T., Liu, H., et al. A functional genome-wide RNAi screen identifies TAF1 as a regulator for apoptosis in response to genotoxic stress. Nucleic Acids Res 36(16) 5250-5259 (2008).

Tavassoli, P., Wafa, L.A., Cheng, H., et al. TAF1

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

/ We also advise you

Cross selling for this product : TAF1 bromodomains 1 and 2 TR-<wbr/>FRET Assay Kit There are 10 products.