Urocortin III (human) (trifluoroacetate salt)

Territorial Availability: Available through Bertin Technologies only in France

• Synonyms
  • L-phenylalanyl-L-threonyl-L-leucyl-L-seryl-L-leucyl-L-?-aspartyl-L-valyl-L-prolyl-L-threonyl-L-asparaginyl-L-isoleucyl-L-methionyl-L-asparaginyl-L-leucyl-L-leucyl-L-phenylalanyl-L-asparaginyl-L-isoleucyl-L-alanyl-L-lysyl-L-alanyl-L-lysyl-L-asparaginyl-L-leucyl-L-arginyl-L-alanyl-L-glutaminyl-L-alanyl-L-alanyl-L-alanyl-L-asparaginyl-L-alanyl-L-histidyl-L-leucyl-L-methionyl-L-alanyl-L-glutaminyl-L-isoleucinamide, 2,2,2-trifluoroacetate
• Correlated keywords
  • anti-depressant CRF-2? 2? 1 357952-09-1
• Product Overview:
  Urocortin III is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF (Item No. 24407), urocortin (Item No. 24745), urocortin II (Item No. 24746), frog sauvagine, and piscine urotensin I.{39576} Human urocortin III shares 90, 40, 37, and 21% identity to mouse urocortin III (Item Nos. 24749 | 24750), mouse urocortin II (Item No. 24747), human urocortin (Item No. 24744), and mouse urocortin, respectively. Urocortin III selectively binds to type 2 CRF receptors (Kis = 21.7, 13.5, and >100 nM for rat CRF2?, rat CRF2?, and human CRF1, respectively). It stimulates cAMP production in CHO cells expressing rat CRF2? and mouse CRF2? (EC50s = 0.16 and 0.12 nM, respectively) as well as cultured anterior pituitary cells expressing endogenous CRF2?. Urocortin III is co-released with insulin to potentiate glucose-stimulated somatostatin release in vitro in human pancreatic ?-cells.{39579} In vivo, urocortin III reduces food intake in a dose- and time-dependent manner in mice with a minimum effective dose (MED) of 0.3 nmol/animal.{41572} It increases swimming time in a forced swim test in mice, indicating antidepressant-like activity.{41573}