URB602

URB602

CAT N°: 10007457
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From 54.00 45.90

URB602 is a selective inhibitor of monoacylglycerol lipase (MAGL), exhibiting an IC50 value of 28 µM for the rat brain enzyme.{13217} It does not inhibit fatty acid amide hydrolase (FAAH) at concentrations up to 100 µM or other lipid metabolizing enzymes such as diacylglycerol lipase or COX-2.{13217,11304} Inhibition of MAGL inhibits 2-arachidonoyl glycerol (Item No. 62160) hydrolysis, which is associated with enhanced stress-induced analgesia and may represent a novel drug target in pain and stress management.{13217} URB602 (50 µM) also inhibits glucose-stimulated and depolarization-induced insulin secretion in INS-1 cells.{38096}

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