From €291.00 €247.35
Trabectedin is an alkaloid that has been found in E. turbinata and has anticancer activity.{58747,58748,58749,58750} It is a guanine-specific DNA alkylating agent and an antagonist of the pregnane X receptor (PXR; IC50 = ~3 nM in a reporter assay).{58747,58748} Trabectedin reduces viability of DU145 and PC3 human prostate cancer stem cells in a concentration-dependent manner and induces apoptosis in DU145 and PC3 cancer stem cells and DU145 and PC3 non-stem cancer cells.{58749} It inhibits tumor growth in a patient-derived orthotopic xenograft (PDOX) mouse model of leiomyosarcoma when administered at a dose of 0.15 mg/kg per week.{58750} Formulations containing trabectedin have been used in the treatment of unresectable or metastatic liposarcoma or leiomyosarcoma.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 500 µg |
|---|---|
| Shipping | dry ice |
| CAS number | 114899-77-3 |
| Molecular formula | C39H43N3O11S |
| Smiles | O[C@@H]([C@]1([H])CC2=CC(C)=C3OC)N([C@](COC4=O)([H])C5=C(OCO6)C6=C7C)[C@@]([C@@](N1C)([H])C2=C3O)([H])[C@@](SC[C@@]4(NCCC8=C9)C8=CC(OC)=C9O)([H])C5=C7OC(C)=O |
| Molecular weight | 761,8 |
| Custom code | 2934.99 |
| Formulation | A solid |
| Purity | ≥95% |
| UNSPSC code | 12352100 |
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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
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