€676.00 €574.60
TMPRSS2 is a type II transmembrane serine protease that has major roles in androgen receptor signaling, viral infection, and carcinogenesis.{62531} TMPRSS2 is composed of an N-terminal transmembrane domain and an extracellular stem region that contains an LDL receptor class A (LDLRA) domain that binds calcium, as well as a scavenger receptor cysteine-rich (SRCR) domain that interacts with other extracellular molecules. It is synthesized as a zymogen and the C-terminal serine protease domain undergoes autoproteolytic cleavage, releasing the soluble protease into the extracellular space. TMPRSS2 mRNA is mainly expressed in the prostate gland but is also found in the salivary and mammary glands, colon, stomach, small intestine, kidney, liver, and lung.{62532} Soluble TMPRSS2 cleaves and activates proteinase-activated receptor 2 (PAR2) in prostate cancer cells.{59138} TMPRSS2 facilitates host cell entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro, and knockout of Tmprss2 in human dipeptidyl peptidase 4-expressing transgenic mice reduces disease severity in a model of Middle East respiratory syndrome coronavirus (MERS-CoV) infection.{49542,49548} Chromosomal translocations leading to TMPRSS2-ERG fusions are associated with prostate cancer.{62533} Cayman’s TMPRSS2 (human, recombinant) protein can be used for enzyme activity assays.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 20 µg |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Formulation | 50 mM Tris-HCl, pH 7.4, with 300 mM sodium chloride and 0.001% NP-40 |
| Purity | ≥90% estimated by SDS-PAGE |
| Custom code | 3504.00 |
| UNSPSC code | 12352204 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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